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Intraventricular Fl...
Intraventricular Flow Patterns in Patients Treated with Left Ventricular Assist Devices
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- Rossini, Lorenzo (author)
- University of California, San Diego
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- Braun, Oscar (author)
- Lund University,Lunds universitet,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,University of California, San Diego
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- Brambatti, Michela (author)
- University of California, San Diego
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- Benito, Yolanda (author)
- Complutense University of Madrid,Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
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- Mizeracki, Adam (author)
- University of California, San Diego
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- Miramontes, Marissa (author)
- University of California, San Diego
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- Nguyen, Cathleen (author)
- University of California, San Diego
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- Martinez-Legazpi, Pablo (author)
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV),Complutense University of Madrid
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- Almeida, Shone (author)
- University of California, San Diego
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- Kraushaar, Megan (author)
- University of California, San Diego
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- Vu, Vi (author)
- San Diego State University
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- May-Newman, Karen (author)
- San Diego State University
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- Bermejo, Javier (author)
- Complutense University of Madrid,Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
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- Adler, Eric D. (author)
- University of California, San Diego
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- Kahn, Andrew M. (author)
- University of California, San Diego
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- Del Alamo, Juan C. (author)
- University of California, San Diego
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(creator_code:org_t)
- 2021
- 2021
- English 10 s.
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In: ASAIO Journal. - 1538-943X. ; 67:1, s. 74-83
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- The success of left ventricular assist device (LVAD) therapy is hampered by complications such as thrombosis and bleeding. Understanding blood flow interactions between the heart and the LVAD might help optimize treatment and decrease complication rates. We hypothesized that LVADs modify shear stresses and blood transit in the left ventricle (LV) by changing flow patterns and that these changes can be characterized using 2D echo color Doppler velocimetry (echo-CDV). We used echo-CDV and custom postprocessing methods to map blood flow inside the LV in patients with ongoing LVAD support (Heartmate II, N = 7). We compared it to healthy controls (N = 20) and patients with dilated cardiomyopathy (DCM, N = 20). We also analyzed intraventricular flow changes during LVAD ramp tests (baseline ± 400 rpm). LVAD support reversed the increase in blood stasis associated with DCM, but it did not reduce intraventricular shear exposure. Within the narrow range studied, the ventricular flow was mostly insensitive to changes in pump speed. Patients with significant aortic insufficiency showed abnormalities in blood stasis and shear indices. Overall, this study suggests that noninvasive flow imaging could potentially be used in combination with standard clinical methods for adjusting LVAD settings to optimize flow transport and minimize stasis on an individual basis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Rossini, Lorenzo
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Braun, Oscar
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Brambatti, Miche ...
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Benito, Yolanda
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Mizeracki, Adam
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Miramontes, Mari ...
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show more...
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Nguyen, Cathleen
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Martinez-Legazpi ...
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Almeida, Shone
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Kraushaar, Megan
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Vu, Vi
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May-Newman, Kare ...
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Bermejo, Javier
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Adler, Eric D.
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Kahn, Andrew M.
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Del Alamo, Juan ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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ASAIO Journal
- By the university
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Lund University