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  • Radhoe, Sumant P.Erasmus University Medical Center (author)

Sex-related differences in left ventricular assist device utilization and outcomes : results from the PCHF-VAD registry

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2022-12-22
  • Wiley,2023
  • 12 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3c22252f-a184-4a4c-a718-dd4dd5d6ae25
  • https://lup.lub.lu.se/record/3c22252f-a184-4a4c-a718-dd4dd5d6ae25URI
  • https://doi.org/10.1002/ehf2.14261DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151517526URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims: Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex-related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort. Methods and results: This analysis is part of the multicentre PCHF-VAD registry studying continuous-flow LVAD patients. The primary outcome was all-cause mortality. Secondary outcomes included ventricular arrhythmias, right ventricular failure, bleeding, thromboembolism, and the haemocompatibility score. Multivariable Cox regression models were used to assess associations between sex and outcomes. Overall, 457 men (81%) and 105 women (19%) were analysed. At LVAD implant, women were more often in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 or 2 (55% vs. 41%, P = 0.009) and more often required temporary mechanical circulatory support (39% vs. 23%, P = 0.001). Mean age was comparable (52.1 vs. 53.4 years, P = 0.33), and median follow-up duration was 344 [range 147–823] days for women and 435 [range 190–816] days for men (P = 0.40). No significant sex-related differences were found in all-cause mortality (hazard ratio [HR] 0.79 for female vs. male sex, 95% confidence interval [CI] [0.50–1.27]). Female LVAD patients had a lower risk of ventricular arrhythmias (HR 0.56, 95% CI [0.33–0.95]) but more often experienced right ventricular failure. No significant sex-related differences were found in other outcomes. Conclusions: In this contemporary European cohort of LVAD patients, far fewer women than men underwent LVAD implantation despite similar clinical outcomes. This is important as the proportion of female LVAD patients (19%) was lower than the proportion of females with advanced HF as reported in previous studies, suggesting underutilization. Also, female patients were remarkably more often in INTERMACS profile 1 or 2, suggesting later referral for LVAD therapy. Additional research in female patients is warranted.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Jakus, NinaUniversity Hospital of Infectious Diseases (author)
  • Veenis, Jesse F.University Hospital of Infectious Diseases (author)
  • Timmermans, PhilippeUniversity Hospitals Leuven (author)
  • Pouleur, Anne CatherineCatholic University of Louvain,Saint-Luc University Hospital (author)
  • Rubís, PawelJagiellonian University (author)
  • Van Craenenbroeck, Emeline M.Antwerp University Hospital (author)
  • Gaizauskas, EdvinasVilnius University (author)
  • Barge-Caballero, EduardoHospital Juan Canalejo (author)
  • Paolillo, StefaniaUniversity of Naples Federico II (author)
  • Grundmann, SebastianAlbert-Ludwigs University Freiburg (author)
  • D'Amario, DomenicoPoliclinico Universitario Agostino Gemelli (author)
  • Braun, OscarLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-oos (author)
  • Gkouziouta, AggelikiOnassis Cardiac Surgery Center, Athens (author)
  • Planinc, IvoUniversity Hospital of Infectious Diseases (author)
  • Macek, Jana LjubasUniversity Hospital of Infectious Diseases (author)
  • Meyns, BartUniversity Hospitals Leuven (author)
  • Droogne, WalterUniversity Hospitals Leuven (author)
  • Wierzbicki, KarolJagiellonian University (author)
  • Holcman, KatarzynaJagiellonian University (author)
  • Flammer, Andreas J.University Hospital of Zurich (author)
  • Gasparovic, HrvojeUniversity Hospital of Infectious Diseases (author)
  • Biocina, BojanUniversity Hospital of Infectious Diseases (author)
  • Milicic, DavorUniversity Hospital of Infectious Diseases (author)
  • Lund, Lars HKarolinska Institutet,Karolinska Institute (author)
  • Ruschitzka, FrankUniversity Hospital of Zurich (author)
  • Brugts, Jasper J.Erasmus University Medical Center (author)
  • Cikes, MajaUniversity Hospital of Infectious Diseases (author)
  • Erasmus University Medical CenterUniversity Hospital of Infectious Diseases (creator_code:org_t)

Related titles

  • In:ESC Heart Failure: Wiley10:2, s. 1054-10652055-5822

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