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Sequencing of 640,0...
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity
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- Akbari, Parsa (author)
- Regeneron Pharmaceuticals, Inc.
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- Gilani, Ankit (author)
- New York Medical College
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- Sosina, Olukayode (author)
- Regeneron Pharmaceuticals, Inc.
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- Kosmicki, Jack A. (author)
- Regeneron Pharmaceuticals, Inc.
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- Khrimian, Lori (author)
- Regeneron Pharmaceuticals, Inc.
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- Fang, Yi Ya (author)
- Regeneron Pharmaceuticals, Inc.
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- Persaud, Trikaldarshi (author)
- Regeneron Pharmaceuticals, Inc.
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- Garcia, Victor (author)
- New York Medical College
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- Sun, Dylan (author)
- Regeneron Pharmaceuticals, Inc.
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- Li, Alexander (author)
- Regeneron Pharmaceuticals, Inc.
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- Mbatchou, Joelle (author)
- Regeneron Pharmaceuticals, Inc.
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- Locke, Adam E. (author)
- Regeneron Pharmaceuticals, Inc.
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- Benner, Christian (author)
- Regeneron Pharmaceuticals, Inc.
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- Verweij, Niek (author)
- Regeneron Pharmaceuticals, Inc.
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- Lin, Nan (author)
- Regeneron Pharmaceuticals, Inc.
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- Hossain, Sakib (author)
- New York Medical College
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- Agostinucci, Kevin (author)
- New York Medical College
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- Pascale, Jonathan V. (author)
- New York Medical College
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- Dirice, Ercument (author)
- New York Medical College
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- Dunn, Michael (author)
- Regeneron Pharmaceuticals, Inc.
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- Kraus, William E. (author)
- Duke University Medical Center
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- Shah, Svati H. (author)
- Duke University Medical Center
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- Chen, Yii Der I. (author)
- University of California, Los Angeles
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- Rotter, Jerome I. (author)
- University of California, Los Angeles
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- Rader, Daniel J. (author)
- University of Pennsylvania
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Still, Christopher D. (author)
- Geisinger Health System
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- Mirshahi, Tooraj (author)
- Geisinger Health System
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- Carey, David J. (author)
- Geisinger Health System
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- Berumen-Campos, Jaime (author)
- National Autonomous University of Mexico
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- Kuri-Morales, Pablo (author)
- National Autonomous University of Mexico
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- Alegre-Díaz, Jesus (author)
- National Autonomous University of Mexico
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- Torres, Jason M. (author)
- University of Oxford
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- Emberson, Jonathan R. (author)
- University of Oxford
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- Collins, Rory (author)
- University of Oxford
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- Balasubramanian, Suganthi (author)
- Regeneron Pharmaceuticals, Inc.
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- Hawes, Alicia (author)
- Regeneron Pharmaceuticals, Inc.
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- Jones, Marcus (author)
- Regeneron Pharmaceuticals, Inc.
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- Zambrowicz, Brian (author)
- Regeneron Pharmaceuticals, Inc.
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- Murphy, Andrew J. (author)
- Regeneron Pharmaceuticals, Inc.
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- Paulding, Charles (author)
- Regeneron Pharmaceuticals, Inc.
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- Coppola, Giovanni (author)
- Regeneron Pharmaceuticals, Inc.
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- Overton, John D. (author)
- Regeneron Pharmaceuticals, Inc.
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- Reid, Jeffrey G. (author)
- Regeneron Pharmaceuticals, Inc.
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- Shuldiner, Alan R. (author)
- Regeneron Pharmaceuticals, Inc.
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- Cantor, Michael (author)
- Regeneron Pharmaceuticals, Inc.
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- Kang, Hyun M. (author)
- Regeneron Pharmaceuticals, Inc.
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- Abecasis, Goncalo R. (author)
- Regeneron Pharmaceuticals, Inc.
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- Karalis, Katia (author)
- Regeneron Pharmaceuticals, Inc.
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- Economides, Aris N. (author)
- Regeneron Pharmaceuticals, Inc.
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- Marchini, Jonathan (author)
- Regeneron Pharmaceuticals, Inc.
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- Yancopoulos, George D (author)
- Regeneron Pharmaceuticals, Inc.
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- Sleeman, Mark W. (author)
- Regeneron Pharmaceuticals, Inc.
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- Altarejos, Judith (author)
- Regeneron Pharmaceuticals, Inc.
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- Gatta, Giusy Della (author)
- Regeneron Pharmaceuticals, Inc.
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- Tapia-Conyer, Roberto (author)
- National Autonomous University of Mexico
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- Schwartzman, Michal L. (author)
- New York Medical College
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- Baras, Aris (author)
- Regeneron Pharmaceuticals, Inc.
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- Ferreira, Manuel A. R. (author)
- Regeneron Pharmaceuticals, Inc.
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- Lotta, Luca A. (author)
- Regeneron Pharmaceuticals, Inc.
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Regeneron Pharmaceuticals, Inc New York Medical College (creator_code:org_t)
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- American Association for the Advancement of Science (AAAS), 2021
- 2021
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 373:6550
- Related links:
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http://dx.doi.org/10...
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https://www.ukbioban...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Large-scale human exome sequencing can identify rare protein-coding variants with a large impact on complex traits such as body adiposity. We sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico and estimated associations of rare coding variants with body mass index (BMI). We identified 16 genes with an exome-wide significant association with BMI, including those encoding five brain-expressed G protein-coupled receptors (CALCR, MC4R, GIPR, GPR151, and GPR75). Protein-truncating variants in GPR75 were observed in ∼4/10,000 sequenced individuals and were associated with 1.8 kilograms per square meter lower BMI and 54% lower odds of obesity in the heterozygous state. Knock out of Gpr75 in mice resulted in resistance to weight gain and improved glycemic control in a high-fat diet model. Inhibition of GPR75 may provide a therapeutic strategy for obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Akbari, Parsa
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Gilani, Ankit
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Sosina, Olukayod ...
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Kosmicki, Jack A ...
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Khrimian, Lori
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Fang, Yi Ya
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show more...
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Persaud, Trikald ...
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Garcia, Victor
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Sun, Dylan
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Li, Alexander
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Mbatchou, Joelle
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Locke, Adam E.
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Benner, Christia ...
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Verweij, Niek
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Lin, Nan
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Hossain, Sakib
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Agostinucci, Kev ...
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Pascale, Jonatha ...
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Dirice, Ercument
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Dunn, Michael
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Kraus, William E ...
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Shah, Svati H.
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Chen, Yii Der I.
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Rotter, Jerome I ...
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Rader, Daniel J.
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Melander, Olle
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Still, Christoph ...
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Mirshahi, Tooraj
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Carey, David J.
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Berumen-Campos, ...
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Kuri-Morales, Pa ...
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Alegre-Díaz, Jes ...
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Torres, Jason M.
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Emberson, Jonath ...
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Collins, Rory
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Balasubramanian, ...
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Hawes, Alicia
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Jones, Marcus
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Zambrowicz, Bria ...
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Murphy, Andrew J ...
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Paulding, Charle ...
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Coppola, Giovann ...
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Overton, John D.
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Reid, Jeffrey G.
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Shuldiner, Alan ...
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Cantor, Michael
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Kang, Hyun M.
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Abecasis, Goncal ...
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Karalis, Katia
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Economides, Aris ...
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Marchini, Jonath ...
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Yancopoulos, Geo ...
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Sleeman, Mark W.
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Altarejos, Judit ...
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Gatta, Giusy Del ...
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Tapia-Conyer, Ro ...
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Schwartzman, Mic ...
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Baras, Aris
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Ferreira, Manuel ...
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Lotta, Luca A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Science
- By the university
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Lund University