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Trans-omics biomark...
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Dong, XuesiNanjing Medical University,Southeast University
(författare)
Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-08-21
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Impact Journals, LLC,2019
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24 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:3d812759-1784-441f-9e44-605fa0ee35bf
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https://lup.lub.lu.se/record/3d812759-1784-441f-9e44-605fa0ee35bfURI
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https://doi.org/10.18632/aging.102189DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Limited studies have focused on developing prognostic models with trans-omics biomarkers for early-stage lung adenocarcinoma (LUAD). We performed integrative analysis of clinical information, DNA methylation, and gene expression data using 825 early-stage LUAD patients from 5 cohorts. Ranger algorithm was used to screen prognosis-associated biomarkers, which were confirmed with a validation phase. Clinical and biomarker information was fused using an iCluster plus algorithm, which significantly distinguished patients into high- and low-mortality risk groups (Pdiscovery = 0.01 and Pvalidation = 2.71×10-3). Further, potential functional DNA methylation-gene expression-overall survival pathways were evaluated by causal mediation analysis. The effect of DNA methylation level on LUAD survival was significantly mediated through gene expression level. By adding DNA methylation and gene expression biomarkers to a model of only clinical data, the AUCs of the trans-omics model improved by 18.3% (to 87.2%) and 16.4% (to 85.3%) in discovery and validation phases, respectively. Further, concordance index of the nomogram was 0.81 and 0.77 in discovery and validation phases, respectively. Based on systematic review of published literatures, our model was superior to all existing models for early-stage LUAD. In summary, our trans-omics model may help physicians accurately identify patients with high mortality risk.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zhang, RuyangHarvard University,Nanjing Medical University,Nanjing University
(författare)
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He, JieyuNanjing Medical University
(författare)
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Lai, LinjingNanjing Medical University
(författare)
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Alolga, Raphael N.China Pharmaceutical University
(författare)
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Shen, SipengNanjing Medical University,Harvard University
(författare)
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Zhu, YingNanjing Medical University
(författare)
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You, DongfangNanjing Medical University
(författare)
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Lin, LijuanNanjing Medical University
(författare)
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Chen, ChaoNanjing Medical University
(författare)
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Zhao, YangNanjing Medical University
(författare)
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Duan, WeiweiNanjing Medical University
(författare)
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Su, LiNanjing Medical University,Harvard University
(författare)
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Shafer, AndreaMassachusetts General Hospital,Harvard University
(författare)
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Salama, MoranBellvitge Biomedical Research Institute,University of Barcelona
(författare)
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Fleischer, ThomasOslo university hospital
(författare)
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Bjaanæs, Maria MoksnesOslo university hospital
(författare)
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Karlsson, AnnaLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups(Swepub:lu)med-akn
(författare)
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Planck, MariaLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups(Swepub:lu)onk-mpl
(författare)
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Wang, RuiNanjing University
(författare)
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Staaf, JohanLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups(Swepub:lu)onk-jst
(författare)
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Helland, ÅslaugOslo university hospital,University of Oslo
(författare)
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Esteller, ManelBellvitge Biomedical Research Institute,University of Barcelona
(författare)
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Wei, YongyueNanjing Medical University,Harvard University
(författare)
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Chen, FengNanjing Medical University,Southeast University
(författare)
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Christiani, David C.Harvard University,Massachusetts General Hospital,Nanjing Medical University
(författare)
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Nanjing Medical UniversitySoutheast University
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Aging: Impact Journals, LLC11:16, s. 6312-63351945-4589
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Aging
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Dong, Xuesi
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Zhang, Ruyang
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He, Jieyu
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Lai, Linjing
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Alolga, Raphael ...
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Shen, Sipeng
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visa fler...
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Zhu, Ying
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You, Dongfang
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Lin, Lijuan
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Chen, Chao
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Zhao, Yang
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Duan, Weiwei
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Su, Li
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Shafer, Andrea
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Salama, Moran
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Fleischer, Thoma ...
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Bjaanæs, Maria M ...
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Karlsson, Anna
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Planck, Maria
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Wang, Rui
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Staaf, Johan
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Helland, Åslaug
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Esteller, Manel
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Wei, Yongyue
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Chen, Feng
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Christiani, Davi ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Aging
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