Search: id:"swepub:oai:lup.lub.lu.se:3dc56d33-c716-435e-9d63-bcb14e4dbbe7" >
Low vitamin d level...
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Marcos-Pérez, DiegoUniversity of A Coruña,Institute of Biomedical Research of A Coruña, INIBIC
(author)
Low vitamin d levels and frailty status in older adults : A systematic review and meta-analysis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-07-30
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MDPI AG,2020
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20 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:3dc56d33-c716-435e-9d63-bcb14e4dbbe7
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https://lup.lub.lu.se/record/3dc56d33-c716-435e-9d63-bcb14e4dbbe7URI
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https://doi.org/10.3390/nu12082286DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried’s phenotype to identify frailty. Twenty-six studies were considered in the qualitative synthesis, and thirteen studies were included in the meta-analyses. Quantitative analyses showed significant differences in the comparisons of frail (standardized mean difference (SMD)—1.31, 95% confidence interval (CI) (−2.47, −0.15), p = 0.0271) and pre-frail (SMD—0.79, 95% CI (−1.58, −0.003), p = 0.0491) subjects vs. non-frail subjects. Sensitivity analyses reduced heterogeneity, resulting in a smaller but still highly significant between-groups difference. Results obtained indicate that lower 25(OH)D levels are significantly associated with increasing frailty severity. Future challenges include interventional studies testing the possible benefits of vitamin D supplementation in older adults to prevent/palliate frailty and its associated outcomes.
Subject headings and genre
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Sánchez-Flores, MaríaUniversity of A Coruña,University of Porto,National Health Institute Doutor Ricardo Jorge, Lisbon
(author)
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Proietti, StefaniaIRCCS San Raffaele Pisana
(author)
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Bonassi, StefanoIRCCS San Raffaele Pisana,San Raffaele Scientific Institute
(author)
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Costa, SolangeUniversity of Porto,National Health Institute Doutor Ricardo Jorge, Lisbon
(author)
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Teixeira, Joao PauloNational Health Institute Doutor Ricardo Jorge, Lisbon,University of Porto
(author)
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Fernández-Tajes, JuanLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,Wellcome Trust Centre for Human Genetics,University of Oxford(Swepub:lu)ju3355fe
(author)
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Pásaro, EduardoInstitute of Biomedical Research of A Coruña, INIBIC,University of A Coruña
(author)
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Valdiglesias, VanessaNational Health Institute Doutor Ricardo Jorge, Lisbon,University of A Coruña,University of Porto
(author)
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Laffon, BlancaUniversity of A Coruña,Institute of Biomedical Research of A Coruña, INIBIC
(author)
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University of A CoruñaInstitute of Biomedical Research of A Coruña, INIBIC
(creator_code:org_t)
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In:Nutrients: MDPI AG12:82072-6643
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