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  • Marcos-Pérez, DiegoUniversity of A Coruña,Institute of Biomedical Research of A Coruña, INIBIC (author)

Low vitamin d levels and frailty status in older adults : A systematic review and meta-analysis

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-07-30
  • MDPI AG,2020
  • 20 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:3dc56d33-c716-435e-9d63-bcb14e4dbbe7
  • https://lup.lub.lu.se/record/3dc56d33-c716-435e-9d63-bcb14e4dbbe7URI
  • https://doi.org/10.3390/nu12082286DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried’s phenotype to identify frailty. Twenty-six studies were considered in the qualitative synthesis, and thirteen studies were included in the meta-analyses. Quantitative analyses showed significant differences in the comparisons of frail (standardized mean difference (SMD)—1.31, 95% confidence interval (CI) (−2.47, −0.15), p = 0.0271) and pre-frail (SMD—0.79, 95% CI (−1.58, −0.003), p = 0.0491) subjects vs. non-frail subjects. Sensitivity analyses reduced heterogeneity, resulting in a smaller but still highly significant between-groups difference. Results obtained indicate that lower 25(OH)D levels are significantly associated with increasing frailty severity. Future challenges include interventional studies testing the possible benefits of vitamin D supplementation in older adults to prevent/palliate frailty and its associated outcomes.

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  • Sánchez-Flores, MaríaUniversity of A Coruña,University of Porto,National Health Institute Doutor Ricardo Jorge, Lisbon (author)
  • Proietti, StefaniaIRCCS San Raffaele Pisana (author)
  • Bonassi, StefanoIRCCS San Raffaele Pisana,San Raffaele Scientific Institute (author)
  • Costa, SolangeUniversity of Porto,National Health Institute Doutor Ricardo Jorge, Lisbon (author)
  • Teixeira, Joao PauloNational Health Institute Doutor Ricardo Jorge, Lisbon,University of Porto (author)
  • Fernández-Tajes, JuanLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,Wellcome Trust Centre for Human Genetics,University of Oxford(Swepub:lu)ju3355fe (author)
  • Pásaro, EduardoInstitute of Biomedical Research of A Coruña, INIBIC,University of A Coruña (author)
  • Valdiglesias, VanessaNational Health Institute Doutor Ricardo Jorge, Lisbon,University of A Coruña,University of Porto (author)
  • Laffon, BlancaUniversity of A Coruña,Institute of Biomedical Research of A Coruña, INIBIC (author)
  • University of A CoruñaInstitute of Biomedical Research of A Coruña, INIBIC (creator_code:org_t)

Related titles

  • In:Nutrients: MDPI AG12:82072-6643

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