New genetic loci link adipose and insulin biology to body fat distribution.

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Shungin, DmitryUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi (author)

New genetic loci link adipose and insulin biology to body fat distribution.

Article/chapterEnglish2015

Publisher, publication year, extent ...

2015-02-11
Springer Science and Business Media LLC,2015

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LIBRIS-ID:oai:lup.lub.lu.se:3e5c03cd-7b22-4d63-b18b-b30b066e7fe9
https://lup.lub.lu.se/record/5144408URI
https://doi.org/10.1038/nature14132DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100950URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244267URI
https://urn.kb.se/resolve?urn=urn:nbn:se:du-21323URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:130690385URI
https://gup.ub.gu.se/publication/213559URI

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Language:English
Summary in:English

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Notes

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Obesity: genetics
Physiologic: genetics
Neovascularization
Insulin Resistance: genetics
Insulin: metabolism
Human: genetics
Genome
Europe: ethnology
Continental Population Groups: genetics
Adipose Tissue: metabolism
Adipocytes: metabolism
Adipogenesis: genetics
Polymorphism
Single Nucleotide: genetics
Quantitative Trait Loci: genetics
Transcription
Genetic: genetics
Hälsa och välfärd

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Winkler, Thomas W (author)
Croteau-Chonka, Damien C (author)
Ferreira, Teresa (author)
Locke, Adam E (author)
Mägi, Reedik (author)
Strawbridge, Rona JKarolinska Institutet (author)
Pers, Tune H (author)
Fischer, Krista (author)
Justice, Anne E (author)
Workalemahu, Tsegaselassie (author)
Wu, Joseph M W (author)
Lind, LarsKarolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Heard-Costa, Nancy L (author)
Sundström, JohanUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)johasund (author)
Drong, Alexander W (author)
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Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732 (author)
Day, Felix R (author)
Esko, Tonu (author)
Fall, ToveUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)tovfa878 (author)
Kutalik, Zoltán (author)
Luan, Jian'an (author)
Randall, Joshua C (author)
Scherag, André (author)
Vedantam, Sailaja (author)
Wood, Andrew R (author)
Chen, Jin (author)
Fehrmann, Rudolf (author)
Karjalainen, Juha (author)
Kahali, Bratati (author)
Liu, Ching-Ti (author)
Schmidt, Ellen M (author)
Absher, Devin (author)
Amin, Najaf (author)
Anderson, Denise (author)
Beekman, Marian (author)
Bragg-Gresham, Jennifer L (author)
Buyske, Steven (author)
Demirkan, Ayse (author)
Ehret, Georg B (author)
Feitosa, Mary F (author)
Goel, Anuj (author)
Jackson, Anne U (author)
Johnson, Toby (author)
Kleber, Marcus E (author)
Hedman, Åsa KUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ashed124 (author)
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Peters, Marjolein J (author)
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Stančáková, Alena (author)
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Yengo, Loïc (author)
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Albrecht, Eva (author)
Ärnlöv, JohanHögskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap,Uppasla universitet(Swepub:du)jan (author)
Arscott, Gillian M (author)
Bandinelli, Stefania (author)
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Clarke, Robert (author)
Daw, E Warwick (author)
Deelen, Joris (author)
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Delgado, Graciela (author)
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Estrada, KarolKarolinska Institutet (author)
Eury, Elodie (author)
Friedrich, Nele (author)
Garcia, Melissa E (author)
Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517 (author)
Gigante, BrunaKarolinska Institutet (author)
Go, Alan S (author)
Golay, Alain (author)
Grallert, Harald (author)
Grammer, Tanja B (author)
Gräßler, Jürgen (author)
Grewal, Jagvir (author)
Groves, Christopher J (author)
Haller, Toomas (author)
Hallmans, GöranUmeå universitet,Näringsforskning,Enheten för biobanksforskning(Swepub:umu)goha0001 (author)
Hartman, Catharina A (author)
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Hayward, Caroline (author)
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Helmer, Quinta (author)
Hillege, Hans L (author)
Holmen, Oddgeir (author)
Hunt, Steven C (author)
Isaacs, Aaron (author)
Ittermann, Till (author)
James, Alan L (author)
Johansson, Ingegerd (author)
Juliusdottir, Thorhildur (author)
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Kinnunen, Leena (author)
Koenig, Wolfgang (author)
Kooner, Ishminder K (author)
Kratzer, Wolfgang (author)
Lamina, Claudia (author)
Leander, KarinKarolinska Institutet (author)
Lee, Nanette R (author)
Lichtner, Peter (author)
Lind, Lars (author)
Lindström, Jaana (author)
Lobbens, Stéphane (author)
Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xlomat (author)
Mach, François (author)
Magnusson, Patrik K EKarolinska Institutet (author)
Mahajan, Anubha (author)
McArdle, Wendy L (author)
Menni, Cristina (author)
Merger, Sigrun (author)
Mihailov, Evelin (author)
Milani, Lili (author)
Mills, Rebecca (author)
Moayyeri, Alireza (author)
Monda, Keri L (author)
Mooijaart, Simon P (author)
Mühleisen, Thomas W (author)
Mulas, Antonella (author)
Müller, Gabriele (author)
Müller-Nurasyid, Martina (author)
Nagaraja, Ramaiah (author)
Nalls, Michael A (author)
Narisu, Narisu (author)
Glorioso, Nicola (author)
Nolte, Ilja M (author)
Olden, Matthias (author)
Rayner, Nigel W (author)
Renström, FridaLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-frm (author)
Ried, Janina S (author)
Robertson, Neil R (author)
Rose, Lynda M (author)
Sanna, Serena (author)
Scharnagl, Hubert (author)
Scholtens, Salome (author)
Sennblad, BengtKarolinska Institutet (author)
Seufferlein, Thomas (author)
Sitlani, Colleen M (author)
Vernon Smith, Albert (author)
Stirrups, Kathleen (author)
Stringham, Heather M (author)
Sundström, Johan (author)
Swertz, Morris A (author)
Swift, Amy J (author)
Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)anncsyva (author)
Tayo, Bamidele O (author)
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Hua Zhao, Jing (author)
Brennan, Eoin P (author)
Choi, Murim (author)
Eriksson, Per (author)
Folkersen, Lasse (author)
Franco-Cereceda, AndersKarolinska Institutet (author)
Gharavi, Ali G (author)
Hedman, Åsa K (author)
Hivert, Marie-France (author)
Huang, Jinyan (author)
Kanoni, Stavroula (author)
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Olsson, ChristianKarolinska Institutet (author)
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Reinmaa, Eva (author)
Salem, Rany M (author)
Sandholm, Niina (author)
Schadt, Eric E (author)
Scott, Robert A (author)
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Claudi-Boehm, Simone (author)
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Danesh, John (author)
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de Geus, Eco J C (author)
Dörr, Marcus (author)
Erbel, Raimund (author)
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Farrall, Martin (author)
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Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly (author)
Männistö, Satu (author)
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Oldehinkel, Albertine J (author)
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Strauch, Konstantin (author)
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Vohl, Marie-Claude (author)
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Wilson, James F (author)
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Bornstein, Stefan R (author)
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Caulfield, Mark J (author)
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Cooper, Richard S (author)
Dedoussis, George (author)
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Froguel, Philippe (author)
Grabe, Hans-Jörgen (author)
Hamsten, AndersKarolinska Institutet (author)
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Kuh, Diana (author)
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Liu, Yongmei (author)
März, Winfried (author)
Munroe, Patricia B (author)
Njølstad, Inger (author)
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Palmer, Colin N A (author)
Pedersen, Nancy L (author)
Perola, Markus (author)
Pérusse, Louis (author)
Peters, Ulrike (author)
Power, Chris (author)
Quertermous, Thomas (author)
Rauramaa, Rainer (author)
Rivadeneira, Fernando (author)
Saaristo, Timo E (author)
Saleheen, Danish (author)
Sinisalo, Juha (author)
Slagboom, P Eline (author)
Snieder, Harold (author)
Spector, Tim D (author)
Thorsteinsdottir, Unnur (author)
Stumvoll, Michael (author)
Tuomilehto, Jaakko (author)
Uitterlinden, André G (author)
Uusitupa, Matti (author)
van der Harst, Pim (author)
Veronesi, Giovanni (author)
Walker, Mark (author)
Wareham, Nicholas J (author)
Watkins, Hugh (author)
Wichmann, H-Erich (author)
Abecasis, Goncalo R (author)
Assimes, Themistocles L (author)
Berndt, Sonja I (author)
Boehnke, Michael (author)
Borecki, Ingrid B (author)
Deloukas, Panos (author)
Franke, Lude (author)
Frayling, Timothy M (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Hunter, David J (author)
Kaplan, Robert C (author)
O'Connell, Jeffrey R (author)
Qi, Lu (author)
Schlessinger, David (author)
Strachan, David P (author)
Stefansson, Kari (author)
van Duijn, Cornelia M (author)
Willer, Cristen J (author)
Visscher, Peter M (author)
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McCarthy, Mark I (author)
Speliotes, Elizabeth K (author)
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Fox, Caroline S (author)
Barroso, Inês (author)
Franks, Paul W (author)
Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425 (author)
Heid, Iris M (author)
Loos, Ruth J F (author)
Cupples, L Adrienne (author)
Morris, Andrew P (author)
Lindgren, Cecilia M (author)
Mohlke, Karen L (author)
Graessler, Juergen (author)
Uusitupa, Math (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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By the author/editor: Shungin, Dmitry; Winkler, Thomas ...; Croteau-Chonka, ...; Ferreira, Teresa; Locke, Adam E; Mägi, Reedik; show more...; Strawbridge, Ron ...; Pers, Tune H; Fischer, Krista; Justice, Anne E; Workalemahu, Tse ...; Wu, Joseph M W; Lind, Lars; Heard-Costa, Nan ...; Sundström, Johan; Drong, Alexander ...; Song, Ci; Gustafsson, Stef ...; Day, Felix R; Esko, Tonu; Fall, Tove; Kutalik, Zoltán; Luan, Jian'an; Randall, Joshua ...; Scherag, André; Vedantam, Sailaj ...; Wood, Andrew R; Chen, Jin; Fehrmann, Rudolf; Karjalainen, Juh ...; Kahali, Bratati; Liu, Ching-Ti; Schmidt, Ellen M; Absher, Devin; Amin, Najaf; Anderson, Denise; Beekman, Marian; Bragg-Gresham, J ...; Buyske, Steven; Demirkan, Ayse; Ehret, Georg B; Feitosa, Mary F; Goel, Anuj; Jackson, Anne U; Johnson, Toby; Kleber, Marcus E; Hedman, Åsa K; Mangino, Massimo; Mateo Leach, Ire ...; Medina-Gomez, Ca ...; Palmer, Cameron ...; Pasko, Dorota; Pechlivanis, Son ...; Peters, Marjolei ...; Prokopenko, Inga; Stančáková, Alen ...; Ju Sung, Yun; Tanaka, Toshiko; Teumer, Alexande ...; Van Vliet-Ostapt ...; Yengo, Loïc; Zhang, Weihua; Albrecht, Eva; Ärnlöv, Johan; Arscott, Gillian ...; Bandinelli, Stef ...; Barrett, Amy; Bellis, Claire; Bennett, Amanda ...; Berne, Christian; Blüher, Matthias; Böhringer, Stefa ...; Bonnet, Fabrice; Böttcher, Yvonne; Bruinenberg, Mar ...; Carba, Delia B; Caspersen, Ida H; Clarke, Robert; Daw, E Warwick; Deelen, Joris; Deelman, Ewa; Delgado, Graciel ...; Doney, Alex S F; Eklund, Niina; Erdos, Michael R; Estrada, Karol; Eury, Elodie; Friedrich, Nele; Garcia, Melissa ...; Giedraitis, Vilm ...; Gigante, Bruna; Go, Alan S; Golay, Alain; Grallert, Harald; Grammer, Tanja B; Gräßler, Jürgen; Grewal, Jagvir; Groves, Christop ...; Haller, Toomas; Hallmans, Göran; Hartman, Cathari ...; Hassinen, Maija; Hayward, Carolin ...; Heikkilä, Kauko; Herzig, Karl-Hei ...; Helmer, Quinta; Hillege, Hans L; Holmen, Oddgeir; Hunt, Steven C; Isaacs, Aaron; Ittermann, Till; James, Alan L; Johansson, Ingeg ...; Juliusdottir, Th ...; Kalafati, Ioanna ...; Kinnunen, Leena; Koenig, Wolfgang; Kooner, Ishminde ...; Kratzer, Wolfgan ...; Lamina, Claudia; Leander, Karin; Lee, Nanette R; Lichtner, Peter; Lindström, Jaana; Lobbens, Stéphan ...; Lorentzon, Matti ...; Mach, François; Magnusson, Patri ...; Mahajan, Anubha; McArdle, Wendy L; Menni, Cristina; Merger, Sigrun; Mihailov, Evelin; Milani, Lili; Mills, Rebecca; Moayyeri, Alirez ...; Monda, Keri L; Mooijaart, Simon ...; Mühleisen, Thoma ...; Mulas, Antonella; Müller, Gabriele; Müller-Nurasyid, ...; Nagaraja, Ramaia ...; Nalls, Michael A; Narisu, Narisu; Glorioso, Nicola; Nolte, Ilja M; Olden, Matthias; Rayner, Nigel W; Renström, Frida; Ried, Janina S; Robertson, Neil ...; Rose, Lynda M; Sanna, Serena; Scharnagl, Huber ...; Scholtens, Salom ...; Sennblad, Bengt; Seufferlein, Tho ...; Sitlani, Colleen ...; Vernon Smith, Al ...; Stirrups, Kathle ...; Stringham, Heath ...; Swertz, Morris A; Swift, Amy J; Syvänen, Ann-Chr ...; Tayo, Bamidele O; Thorand, Barbara; Thorleifsson, Gu ...; Tomaschitz, Andr ...; Troffa, Chiara; van Oort, Floor ...; Verweij, Niek; Vonk, Judith M; Waite, Lindsay L; Wennauer, Roman; Wilsgaard, Tom; Wojczynski, Mary ...; Wong, Andrew; Zhang, Qunyuan; Hua Zhao, Jing; Brennan, Eoin P; Choi, Murim; Eriksson, Per; Folkersen, Lasse; Franco-Cereceda, ...; Gharavi, Ali G; Hivert, Marie-Fr ...; Huang, Jinyan; Kanoni, Stavroul ...; Karpe, Fredrik; Keildson, Sarah; Kiryluk, Krzyszt ...; Liang, Liming; Lifton, Richard ...; Ma, Baoshan; McKnight, Amy J; McPherson, Ruth; Metspalu, Andres; Min, Josine L; Moffatt, Miriam ...; Montgomery, Gran ...; Murabito, Joanne ...; Nicholson, Georg ...; Nyholt, Dale R; Olsson, Christia ...; Perry, John R B; Reinmaa, Eva; Salem, Rany M; Sandholm, Niina; Schadt, Eric E; Scott, Robert A; Stolk, Lisette; Vallejo, Edgar E; Westra, Harm-Jan; Zondervan, Krina ...; Amouyel, Philipp ...; Arveiler, Domini ...; Bakker, Stephan ...; Beilby, John; Bergman, Richard ...; Blangero, John; Brown, Morris J; Burnier, Michel; 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McKenzie, Colin ...; McKnight, Barbar ...; Musk, Arthur W; Möhlenkamp, Stef ...; Morris, Andrew D; Nelis, Mari; Ohlsson, Claes, ...; Oldehinkel, Albe ...; Ong, Ken K; Palmer, Lyle J; Penninx, Brenda ...; Peters, Annette; Pramstaller, Pet ...; Raitakari, Olli ...; Rankinen, Tuomo; Rao, D C; Rice, Treva K; Ridker, Paul M; Ritchie, Marylyn ...; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J; Saramies, Jouko; Sarzynski, Mark ...; Schwarz, Peter E ...; Shuldiner, Alan ...; Staessen, Jan A; Steinthorsdottir ...; Stolk, Ronald P; Strauch, Konstan ...; Tönjes, Anke; Tremblay, Angelo; Tremoli, Elena; Vohl, Marie-Clau ...; Völker, Uwe; Vollenweider, Pe ...; Wilson, James F; Witteman, Jacque ...; Adair, Linda S; Bochud, Murielle; Boehm, Bernhard ...; Bornstein, Stefa ...; Bouchard, Claude; Cauchi, Stéphane; Caulfield, Mark ...; Chambers, John C; Chasman, Daniel ...; Cooper, Richard ...; Dedoussis, Georg ...; Ferrucci, Luigi; Froguel, Philipp ...; Grabe, Hans-Jörg ...; Hamsten, Anders; Hui, Jennie; 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