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  • Chen, ChaoNanjing Medical University (author)

Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-06-08
  • Impact Journals, LLC,2020
  • 21 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3e74ad5b-c398-4ceb-af62-8f1d9ee8414b
  • https://lup.lub.lu.se/record/3e74ad5b-c398-4ceb-af62-8f1d9ee8414bURI
  • https://doi.org/10.18632/aging.103284DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We performed a methylation-age interaction analysis using 1,230 early-stage lung adenocarcinoma patients from five cohorts. A Cox proportional hazards model was used to investigate lung adenocarcinoma and squamous cell carcinoma patients for methylation-age interactions, which were further confirmed in a validation phase. We identified one adenocarcinoma-specific CpG probe, cg14326354PRODH, with effects significantly modified by age (HRinteraction = 0.989; 95% CI: 0.986-0.994; P = 9.18×10-7). The effect of low methylation was reversed for young and elderly patients categorized by the boundary of 95% CI standard (HRyoung = 2.44; 95% CI: 1.26-4.72; P = 8.34×10-3; HRelderly = 0.58; 95% CI: 0.42-0.82; P = 1.67×10-3). Moreover, there was an antagonistic interaction between low cg14326354PRODH methylation and elderly age (HRinteraction = 0.21; 95% CI: 0.11-0.40; P = 2.20×10-6). In summary, low methylation of cg14326354PRODH might benefit survival of elderly lung adenocarcinoma patients, providing new insight to age-specific prediction and potential drug targeting.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wei, YongyueHarvard University,Nanjing Medical University (author)
  • Wei, LiangminNanjing Medical University (author)
  • Chen, JiajinNanjing Medical University (author)
  • Chen, XinNanjing Medical University (author)
  • Dong, XuesiNanjing Medical University,Southeast University (author)
  • He, JieyuNanjing Medical University (author)
  • Lin, LijuanNanjing Medical University,Harvard University (author)
  • Zhu, YingNanjing Medical University (author)
  • Huang, HuiNanjing Medical University (author)
  • You, DongfangHarvard University,Nanjing Medical University (author)
  • Lai, LinjingNanjing Medical University (author)
  • Shen, SipengNanjing Medical University,Harvard University (author)
  • Duan, WeiweiNanjing Medical University (author)
  • Su, LiHarvard University,Nanjing Medical University (author)
  • Shafer, AndreaMassachusetts General Hospital,Harvard University (author)
  • Fleischer, ThomasOslo university hospital (author)
  • Bjaanæs, Maria MoksnesOslo university hospital (author)
  • Karlsson, AnnaLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-akn (author)
  • Planck, MariaLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-mpl (author)
  • Wang, RuiJinling Hospital, Nanjing,Nanjing University (author)
  • Staaf, JohanLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-jst (author)
  • Helland, ÅslaugUniversity of Oslo,Oslo university hospital (author)
  • Esteller, ManelSpanish Center for Biomedical Research Network in Oncology (CIBERONC),Catalan Institution for Research and Advanced Studies,University of Barcelona,Josep Carreras Leukaemia Research Institute (IJC) (author)
  • Zhang, RuyangJinling Hospital, Nanjing,Nanjing University,Nanjing Medical University (author)
  • Chen, FengNanjing Medical University (author)
  • Christiani, David C.Harvard University,Massachusetts General Hospital (author)
  • Nanjing Medical UniversityHarvard University (creator_code:org_t)

Related titles

  • In:Aging: Impact Journals, LLC12:11, s. 10642-106621945-4589

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