Search: (((L773:1552 5279 OR L773:1552 5260) lar1:(lu) pers:(Ossenkoppele Rik))) >
Comorbid amyloid-β ...
Comorbid amyloid-β pathology affects clinical and imaging features in VCD
-
- Leijenaar, Jolien F. (author)
- Vrije Universiteit Amsterdam
-
- Groot, Colin (author)
- Vrije Universiteit Amsterdam
-
- Sudre, Carole H. (author)
- University College London,King's College London
-
show more...
-
- Bergeron, David (author)
- Laval University
-
- Leeuwis, Anna E. (author)
- Vrije Universiteit Amsterdam
-
- Cardoso, M. Jorge (author)
- University College London,King's College London
-
- Carrasco, Ferran Prados (author)
- University College London
-
- Laforce, Robert (author)
- Laval University
-
- Barkhof, Frederik (author)
- University College London
-
- van der Flier, Wiesje M. (author)
- Vrije Universiteit Amsterdam
-
- Scheltens, Philip (author)
- Vrije Universiteit Amsterdam
-
- Prins, Niels D. (author)
- Vrije Universiteit Amsterdam
-
- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam
-
show less...
-
(creator_code:org_t)
- 2020-01-04
- 2020
- English 11 s.
-
In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 16:2, s. 354-364
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Introduction: To date, the clinical relevance of comorbid amyloid-β (Aβ) pathology in patients with vascular cognitive disorders (VCD) is largely unknown. Methods: We included 218 VCD patients with available cerebrospinal fluid Aβ42 levels. Patients were divided into Aβ+ mild-VCD (n = 84), Aβ− mild-VCD (n = 68), Aβ+ major-VCD (n = 31), and Aβ− major-VCD (n = 35). We measured depression with the Geriatric Depression Scale, cognition with a neuropsychological test battery and derived white matter hyperintensities (WMH) and gray matter atrophy from MRI. Results: Aβ− patients showed more depressive symptoms than Aβ+. In the major-VCD group, Aβ− patients performed worse on attention (P =.02) and executive functioning (P =.008) than Aβ+. We found no cognitive differences in patients with mild VCD. In the mild-VCD group, Aβ− patients had more WMH than Aβ+ patients, whereas conversely, in the major-VCD group, Aβ+ patients had more WMH. Atrophy patterns did not differ between Aβ+ and Aβ− VCD group. Discussion: Comorbid Aβ pathology affects the manifestation of VCD, but effects differ by severity of VCD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Amyloid-β
- Cognition
- Gray matter atrophy
- MRI
- Vascular cognitive disorders
- Vascular dementia
- White matter hyperintensities
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Leijenaar, Jolie ...
-
Groot, Colin
-
Sudre, Carole H.
-
Bergeron, David
-
Leeuwis, Anna E.
-
Cardoso, M. Jorg ...
-
show more...
-
Carrasco, Ferran ...
-
Laforce, Robert
-
Barkhof, Frederi ...
-
van der Flier, W ...
-
Scheltens, Phili ...
-
Prins, Niels D.
-
Ossenkoppele, Ri ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Alzheimer's and ...
- By the university
-
Lund University