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APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome

Lagging, Cecilia (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
Lorentzen, Erik, 1974 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Core Facilities, Bioinformatics,Core Facilities, Bioinformatics
Stanne, Tara M, 1979 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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Pedersen, Annie, 1981 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
Söderholm, Martin (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital
Cole, John W. (author)
University of Maryland,Baltimore Veterans Administration Medical Center
Jood, Katarina, 1966 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Lemmens, Robin (author)
Catholic University of Leuven,University Hospitals Leuven
Phuah, Chia Ling (author)
Washington University in St. Louis
Rost, Natalia S. (author)
Harvard University,Massachusetts General Hospital
Thijs, Vincent (author)
University of Melbourne,Austin Health
Woo, Daniel (author)
University of Cincinnati
Maguire, Jane M. (author)
Hunter Medical Research Institute, Australia,University of Technology Sydney
Lindgren, Arne (author)
Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups
Jern, Christina, 1962 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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2019
2019
English 5 s.
In: Neurology. - 1526-632X. ; 93:19, s. 849-853
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on outcome have been reported.5 Taken together, there is a need for larger studies on APOE and ischemic stroke outcomes with integrated information on age, severity, and sex.The 3 common APOE alleles ε2, ε3, and ε4 can be separated by a combination of 2 single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Thus, associations with APOE alleles are not directly captured in a regular genome-wide association study (GWAS), where each SNP is investigated separately. We derived the 3 common APOE alleles and investigated the interplay between APOE, age at ischemic stroke onset, severity, sex, and outcome within a large international collaboration, the Genetics of Ischaemic Stroke Functional Outcome (GISCOME) network.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

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