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APOE ε4 is associat...
APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome
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- Lagging, Cecilia (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Lorentzen, Erik, 1974 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Core Facilities, Bioinformatics,Core Facilities, Bioinformatics
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- Stanne, Tara M, 1979 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Pedersen, Annie, 1981 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Söderholm, Martin (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Cole, John W. (author)
- University of Maryland,Baltimore Veterans Administration Medical Center
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- Jood, Katarina, 1966 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Lemmens, Robin (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Phuah, Chia Ling (author)
- Washington University in St. Louis
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- Rost, Natalia S. (author)
- Harvard University,Massachusetts General Hospital
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- Thijs, Vincent (author)
- University of Melbourne,Austin Health
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- Woo, Daniel (author)
- University of Cincinnati
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- Maguire, Jane M. (author)
- Hunter Medical Research Institute, Australia,University of Technology Sydney
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- Lindgren, Arne (author)
- Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- 2019
- 2019
- English 5 s.
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In: Neurology. - 1526-632X. ; 93:19, s. 849-853
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on outcome have been reported.5 Taken together, there is a need for larger studies on APOE and ischemic stroke outcomes with integrated information on age, severity, and sex.The 3 common APOE alleles ε2, ε3, and ε4 can be separated by a combination of 2 single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Thus, associations with APOE alleles are not directly captured in a regular genome-wide association study (GWAS), where each SNP is investigated separately. We derived the 3 common APOE alleles and investigated the interplay between APOE, age at ischemic stroke onset, severity, sex, and outcome within a large international collaboration, the Genetics of Ischaemic Stroke Functional Outcome (GISCOME) network.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Neurology
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- By the author/editor
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Lagging, Cecilia
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Lorentzen, Erik, ...
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Stanne, Tara M, ...
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Pedersen, Annie, ...
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Söderholm, Marti ...
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Cole, John W.
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Jood, Katarina, ...
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Lemmens, Robin
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Phuah, Chia Ling
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Rost, Natalia S.
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Thijs, Vincent
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Woo, Daniel
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Maguire, Jane M.
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Lindgren, Arne
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Jern, Christina, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurology
- By the university
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Lund University
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University of Gothenburg