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Cardiovascular dise...
Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
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- Rydell, Andreas (author)
- Karolinska Institutet,Karolinska Institute
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- Nerpin, Elisabet, 1962- (author)
- Dalarna University College,Högskolan Dalarna,Uppsala universitet,Lung- allergi- och sömnforskning,School of Health and Welfare, Dalarna University,Medicinsk vetenskap,Uppsala University, Uppsala
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- Zhou, Xingwu (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University, Uppsala
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi,Uppsala University, Uppsala
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- Lindberg, Eva (author)
- Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala
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- Theorell-Haglöw, Jenny (author)
- Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala
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- Fall, Tove, 1979- (author)
- Uppsala universitet,Molekylär epidemiologi,Uppsala University, Uppsala
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala
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- Lisspers, Karin, Docent, 1954- (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Uppsala University, Uppsala
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- Elmståhl, Sölve (author)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups
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- Zaigham, Suneela (author)
- Lund University,Lunds universitet,Uppsala universitet,Klinisk fysiologi,Department of Clinical Sciences, Lund University,Uppsala University, Uppsala; Lund University, Malmö,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Ärnlöv, Johan, 1970- (author)
- Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge; Region Dalarna, Falun
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Klinisk fysiologi,Uppsala University, Uppsala
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(creator_code:org_t)
- 2023-01-26
- 2023
- English.
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In: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 9:2
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio.METHODS: We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort.RESULTS: Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity.CONCLUSIONS: Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Lung Medicine
- Lungmedicin
- Physiology
- Fysiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rydell, Andreas
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Nerpin, Elisabet ...
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Zhou, Xingwu
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Lind, Lars
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Lindberg, Eva
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Theorell-Haglöw, ...
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show more...
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Fall, Tove, 1979 ...
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Janson, Christer
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Lisspers, Karin, ...
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Elmståhl, Sölve
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Zaigham, Suneela
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Melander, Olle
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Nilsson, Peter M ...
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Ärnlöv, Johan, 1 ...
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Malinovschi, And ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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ERJ Open Researc ...
- By the university
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Uppsala University
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Högskolan Dalarna
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Lund University
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Karolinska Institutet