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  • Wu, ChuanyanLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Shandong Management University,Shandong University,Lund Univ, Dept Clin Sci, Malmö, Sweden.;Shandong Univ, Sch Control Sci & Engn, Jinan, Shandong, Peoples R China.;Shandong Management Univ, Sch Intelligent Engn, Jinan, Shandong, Peoples R China. (author)

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-11-10
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3ffb542e-fb4d-4c5e-a905-9d4b765a4570
  • https://lup.lub.lu.se/record/3ffb542e-fb4d-4c5e-a905-9d4b765a4570URI
  • https://doi.org/10.1038/s41467-021-26536-wDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-305339URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • QC 20211130
  • The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.24 (CI: 1.04-1.47, p < 0.05) during 19-year follow-up (n = 4060, Sweden); and 1.31 (CI: 1.09-1.58, p < 0.01) during 4-year follow-up (n = 883, Finland). High circulating follistatin associates with adipose tissue insulin resistance and non-alcoholic fatty liver disease (n = 210, Germany). In human adipocytes, follistatin dose-dependently increases free fatty acid release. In genome-wide association study (GWAS), variation in the glucokinase regulatory protein gene (GCKR) associates with plasma follistatin levels (n = 4239, Sweden; n = 885, UK, Italy and Sweden) and GCKR regulates follistatin secretion in hepatocytes in vitro. Our findings suggest that GCKR regulates follistatin secretion and that elevated circulating follistatin associates with an increased risk of T2D by inducing adipose tissue insulin resistance.

Subject headings and genre

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  • Borné, YanLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)med-boy (author)
  • Gao, RuiShandong University (author)
  • López Rodriguez, MaykelUniversity of Eastern Finland (author)
  • Roell, William CEli Lilly and Company (author)
  • Wilson, Jonathan MEli Lilly and Company (author)
  • Regmi, AjitEli Lilly and Company (author)
  • Luan, ChengLund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups(Swepub:lu)med-cgl (author)
  • Aly, Dina MansourLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)di3053ma (author)
  • Peter, AndreasUniversity Hospital of Tubingen (author)
  • Machann, JürgenUniversity of Tübingen (author)
  • Staiger, HaraldUniversity Hospital of Tubingen (author)
  • Fritsche, AndreasUniversity Hospital of Tubingen (author)
  • Birkenfeld, Andreas LUniversity Hospital of Tubingen (author)
  • Tao, RongyaHarvard Medical School (author)
  • Wagner, RobertUniversity Hospital of Tubingen (author)
  • Canouil, MickaëlLille University Hospital (author)
  • Hong, Mun-GwanKTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u19gmsru (author)
  • Schwenk, Jochen M.KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u1h7wtme (author)
  • Ahlqvist, EmmaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)infl-eah (author)
  • Kaikkonen, Minna UUniversity of Eastern Finland (author)
  • Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
  • Shore, Angela CRoyal Devon & Exeter Hospital (author)
  • Khan, FaiselUniversity of Dundee (author)
  • Natali, AndreaUniversity of Pisa (author)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
  • Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (author)
  • Nilsson, JanLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-jni (author)
  • Häring, Hans-UlrichUniversity Hospital of Tubingen (author)
  • Renström, ErikLund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups(Swepub:lu)mphy-ere (author)
  • Wollheim, Claes BLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups(Swepub:lu)med-cwe (author)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
  • Weng, JianpingUniversity of Science and Technology of China (author)
  • Pearson, Ewan RUniversity of Dundee(Swepub:lu)ew1481pe (author)
  • Franks, Paul WLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf (author)
  • White, Morris FHarvard Medical School (author)
  • Duffin, Kevin LEli Lilly and Company (author)
  • Vaag, Allan ArthurSteno Diabetes Center Copenhagen(Swepub:lu)med-ava (author)
  • Laakso, MarkkuUniversity of Eastern Finland (author)
  • Stefan, NorbertUniversity Hospital of Tubingen (author)
  • Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr (author)
  • De Marinis, YangLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Shandong University,University of Science and Technology of China,Lund Univ, Dept Clin Sci, Malmö, Sweden.;Shandong Univ, Sch Control Sci & Engn, Jinan, Shandong, Peoples R China.;Univ Sci & Technol China, Dept Endocrinol & Metab, Div Life Sci Med, Hefei, Peoples R China.(Swepub:lu)wbl-yzh (author)
  • Translationell muskelforskningForskargrupper vid Lunds universitet (creator_code:org_t)

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  • In:Nature Communications: Springer Science and Business Media LLC12, s. 1-102041-1723

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