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Elevated circulatin...
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
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- Wu, Chuanyan (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Shandong Management University,Lund Univ, Dept Clin Sci, Malmö, Sweden.;Shandong Univ, Sch Control Sci & Engn, Jinan, Shandong, Peoples R China.;Shandong Management Univ, Sch Intelligent Engn, Jinan, Shandong, Peoples R China.
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- Borné, Yan (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Gao, Rui (author)
- Shandong University
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- López Rodriguez, Maykel (author)
- University of Eastern Finland
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- Roell, William C (author)
- Eli Lilly and Company
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- Wilson, Jonathan M (author)
- Eli Lilly and Company
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- Regmi, Ajit (author)
- Eli Lilly and Company
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- Luan, Cheng (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Aly, Dina Mansour (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Peter, Andreas (author)
- University Hospital of Tubingen
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- Machann, Jürgen (author)
- University of Tübingen
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- Staiger, Harald (author)
- University Hospital of Tubingen
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- Fritsche, Andreas (author)
- University Hospital of Tubingen
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- Birkenfeld, Andreas L (author)
- University Hospital of Tubingen
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- Tao, Rongya (author)
- Harvard Medical School
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- Wagner, Robert (author)
- University Hospital of Tubingen
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- Canouil, Mickaël (author)
- Lille University Hospital
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- Hong, Mun-Gwan (author)
- KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Schwenk, Jochen M. (author)
- KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Kaikkonen, Minna U (author)
- University of Eastern Finland
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Shore, Angela C (author)
- Royal Devon & Exeter Hospital
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- Khan, Faisel (author)
- University of Dundee
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- Natali, Andrea (author)
- University of Pisa
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Häring, Hans-Ulrich (author)
- University Hospital of Tubingen
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- Renström, Erik (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Wollheim, Claes B (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Weng, Jianping (author)
- University of Science and Technology of China
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- Pearson, Ewan R (author)
- University of Dundee
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- Franks, Paul W (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- White, Morris F (author)
- Harvard Medical School
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- Duffin, Kevin L (author)
- Eli Lilly and Company
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- Vaag, Allan Arthur (author)
- Steno Diabetes Center Copenhagen
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- Laakso, Markku (author)
- University of Eastern Finland
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- Stefan, Norbert (author)
- University Hospital of Tubingen
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- De Marinis, Yang (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Science and Technology of China,Shandong University,Lund Univ, Dept Clin Sci, Malmö, Sweden.;Shandong Univ, Sch Control Sci & Engn, Jinan, Shandong, Peoples R China.;Univ Sci & Technol China, Dept Endocrinol & Metab, Div Life Sci Med, Hefei, Peoples R China.
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(creator_code:org_t)
- 2021-11-10
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12, s. 1-10
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https://www.nature.c...
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.24 (CI: 1.04-1.47, p < 0.05) during 19-year follow-up (n = 4060, Sweden); and 1.31 (CI: 1.09-1.58, p < 0.01) during 4-year follow-up (n = 883, Finland). High circulating follistatin associates with adipose tissue insulin resistance and non-alcoholic fatty liver disease (n = 210, Germany). In human adipocytes, follistatin dose-dependently increases free fatty acid release. In genome-wide association study (GWAS), variation in the glucokinase regulatory protein gene (GCKR) associates with plasma follistatin levels (n = 4239, Sweden; n = 885, UK, Italy and Sweden) and GCKR regulates follistatin secretion in hepatocytes in vitro. Our findings suggest that GCKR regulates follistatin secretion and that elevated circulating follistatin associates with an increased risk of T2D by inducing adipose tissue insulin resistance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Wu, Chuanyan
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Borné, Yan
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Gao, Rui
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López Rodriguez, ...
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Roell, William C
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Wilson, Jonathan ...
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show more...
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Regmi, Ajit
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Luan, Cheng
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Aly, Dina Mansou ...
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Peter, Andreas
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Machann, Jürgen
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Staiger, Harald
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Fritsche, Andrea ...
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Birkenfeld, Andr ...
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Tao, Rongya
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Wagner, Robert
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Canouil, Mickaël
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Hong, Mun-Gwan
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Schwenk, Jochen ...
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Ahlqvist, Emma
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Kaikkonen, Minna ...
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Nilsson, Peter
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Shore, Angela C
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Khan, Faisel
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Natali, Andrea
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Melander, Olle
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Orho-Melander, M ...
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Nilsson, Jan
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Häring, Hans-Ulr ...
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Renström, Erik
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Wollheim, Claes ...
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Engström, Gunnar
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Weng, Jianping
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Pearson, Ewan R
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Franks, Paul W
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White, Morris F
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Duffin, Kevin L
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Vaag, Allan Arth ...
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Laakso, Markku
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Stefan, Norbert
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Groop, Leif
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De Marinis, Yang
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Nature Communica ...
- By the university
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Lund University
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Royal Institute of Technology