Photobleaching-Insensitive Fluorescence Diagnostics in Skin and Brain Tissue

Brydegaard, MikkelLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Department of Physics, Lund University (författare)

In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-based fluorescence spectroscopy system. We have developed an effective method for the parameterization of sequences of bleaching spectra. We analyze convergence and decay rates with respect to initial conditions and excitation irradiance. We also discuss the consequences and the potential for bleaching-insensitive measurements and their applicability in a few examples from in vivo open brain surgery.

NATURVETENSKAP Fysik Atom- och molekylfysik och optik hsv//swe
NATURAL SCIENCES Physical Sciences Atom and Molecular Physics and Optics hsv//eng
Fluorescence-guided resection
FGR
5-ALA
PpIX
protoporphyrin
photobleaching
laser-induced fluorescence spectroscopy
LIF
optical
diagnostics
tissue optics
skin
brain
dynamic models
system
identification
state space models
Fluorescence-guided resection
TECHNOLOGY

Haj-Hosseini, NedaLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT(Swepub:liu)nedha71 (författare)
Wårdell, KarinLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT(Swepub:liu)karwa46 (författare)
Andersson-Engels, StefanLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Department of Physics, Lund University(Swepub:lu)fysi-san (författare)
AtomfysikFysiska institutionen (creator_code:org_t)

Ingår i:IEEE Photonics Journal: Institute of Electrical and Electronics Engineers3:3, s. 407-4211943-0655

Av författaren/redakt...: Brydegaard, Mikk ...; Haj-Hosseini, Ne ...; Wårdell, Karin; Andersson-Engels ...

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.