Mechanistic modelling of drug release from a polymer matrix using magnetic resonance microimaging.

Kaunisto, ErikLund University,Lunds universitet,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH (author)

In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer dissolution model. The results are then combined with drug parameters obtained from literature data in the new model to predict solvent and drug concentration profiles and polymer and drug release profiles. The modelling approach was applied to the case of a HPMC matrix highly loaded with mannitol (model drug). The results showed that the drug release rate can be successfully predicted, using the suggested modelling approach. However, the model was not able to accurately predict the polymer release profile, possibly due to the sparse amount of usable pure polymer dissolution data. In addition to the case study, a sensitivity analysis of model parameters relevant to drug release was performed. The analysis revealed important information that can be useful in the drug formulation process.

Tajarobi, Farhad,1971AstraZeneca AB(Swepub:cth)farhad (author)
Abrahmsen-Alami, SusannaAstraZeneca AB (author)
Larsson, Anette,1966Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)anettel (author)
Nilsson, BerntLund University,Lunds universitet,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)kat-bni (author)
Axelsson, AndersLund University,Lunds universitet,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)kat-aax (author)
Avdelningen för kemiteknikInstitutionen för processteknik och tillämpad biovetenskap (creator_code:org_t)

In:European Journal of Pharmaceutical Sciences: Elsevier BV48:4-5, s. 698-7081879-07200928-0987

By the author/editor: Kaunisto, Erik; Tajarobi, Farhad ...; Abrahmsen-Alami, ...; Larsson, Anette, ...; Nilsson, Bernt; Axelsson, Anders

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

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