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  • Liapi, MatinaSkåne University Hospital,Lund University (author)

Venous thromboembolism in ANCA-associated vasculitis : A population-based cohort study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-01-28
  • Oxford University Press (OUP),2021
  • 8 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:41bb09e6-d97f-4c2e-8895-f09a01a23051
  • https://lup.lub.lu.se/record/41bb09e6-d97f-4c2e-8895-f09a01a23051URI
  • https://doi.org/10.1093/rheumatology/keab057DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: To determine incidence rate and predictors of venous thromboembolic events (VTE) in a population-based cohort with ANCA-associated vasculitis (AAV). Methods: The study comprised 325 patients diagnosed with AAV from 1997 to 2016. All cases of VTE from prior to vasculitis diagnosis to the end of the study period were identified. The BVAS was used to assess disease activity at diagnosis. Venous thromboembolisms occurring in a period beginning 3 months prior to AAV diagnosis were considered to be AAV-related. The standardized incidence ratio (SIR) and 95% CI of VTE were calculated using the incidence rate in the general population. Results: Fifty-nine patients (18%) suffered 64 VTE events. Of these, 48 (81%) suffered AAV-related VTE [deep vein thrombosis (n = 23), pulmonary embolism (n = 18) and other (n = 9)]. The incidence rate of AAV-related VTE was 2.4 per 100 person-years (95% CI 1.7, 3.0) during 2039 person-years of follow-up. The incidence during the first 3 months post-AAV diagnosis was 20.4 per 100 person-years (95% CI 11.5, 29.4), decreasing to 8.9 (95% CI 0.2, 17.6) and 1.5 (95% CI 0.0, 3.5) in months 4-6 and months 7-12 post-AAV diagnosis, respectively. The SIR was 34.2 (95% CI 20.2, 48.1) for deep vein thrombosis and 10.4 (95% CI 5.6, 15.1) for pulmonary embolism. In multivariate Cox regression analyses, only age and BVAS were predictive of VTE. Conclusions: The incidence rate and SIR of AAV-related VTE is high, and higher early in the course of the disease. Vasculitis activity and age are positively associated with VTE.

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  • Jayne, DavidUniversity of Cambridge (author)
  • Merkel, Peter A.University of Pennsylvania (author)
  • Segelmark, MårtenLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)njur-mse (author)
  • Mohammad, Aladdin J.Lund University,Lunds universitet,Lund Vasculitis Epidemiology Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Cambridge,Skåne University Hospital(Swepub:lu)reum-amo (author)
  • Skåne University HospitalLund University (creator_code:org_t)

Related titles

  • In:Rheumatology (United Kingdom): Oxford University Press (OUP)60:10, s. 4616-46231462-03241462-0332

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Liapi, Matina
Jayne, David
Merkel, Peter A.
Segelmark, Mårte ...
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
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and Rheumatology and ...
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