Search: WFRF:(Gron Christian) >
Early Surfactant Gu...
Early Surfactant Guided by Lamellar Body Counts on Gastric Aspirate in Very Preterm Infants
-
- Verder, Henrik (author)
- Department of Pediatrics, Holbæk Hospital, Holbæk, Denmark
-
- Ebbesen, Finn (author)
- Department of Pediatrics, Aalborg Hospital, Aalborg, Denmark
-
- Fenger-Gron, Jesper (author)
- Department of Pediatrics, Kolding Hospital, Aarhus University, Aarhus, Denmark
-
show more...
-
- Henriksen, Tine Brink (author)
- Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark
-
- Andreasson, Bengt (author)
- Department of Neonatology, Malmö, Sweden
-
- Bender, Lars (author)
- Department of Pediatrics, Aalborg Hospital, Aalborg, Denmark
-
- Bertelsen, Aksel (author)
- Department of Pediatrics, Holbæk Hospital, Holbæk, Denmark
-
- Björklund, Lars (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Neonatology, Skåne University Hospital, University of Lund, Lund, Sweden
-
- Dahl, Marianne (author)
- Department of Pediatrics, Odense Hospital, Odense, Denmark
-
- Esberg, Gitte (author)
- Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark
-
- Eschen, Christian (author)
- Department of Pediatrics, Holbæk Hospital, Holbæk, Denmark
-
- Hovring, Marie (author)
- Department of Pediatrics, Holbæk Hospital, Holbæk, Denmark
-
- Kreft, Andreas (author)
- Department of Pediatrics, Sønderborg Hospital, University of South Denmark, Sønderborg, Denmark
-
- Kroner, Jorn (author)
- Department of Pediatrics, Odense Hospital, Odense, Denmark
-
- Lundberg, Fredrik (author)
- Department of Neonatology, Malmö, Sweden
-
- Pedersen, Pernille (author)
- epartment of Pediatrics, Hvidovre Hospital, Hvidovre, Denmark
-
- Reinholdt, Jes (author)
- Department of Neonatology, Rigshospitalet, Copenhagen, Denmark
-
- Stanchev, Hristo (author)
- Department of Pediatrics, University of Copenhagen, Næstved, Denmark
-
show less...
-
(creator_code:org_t)
- 2013-07-09
- 2013
- English.
-
In: Neonatology. - : S. Karger AG. - 1661-7800 .- 1661-7819. ; 104:2, s. 116-122
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Background: We have developed a rapid method, based on lamellar body counts (LBC) on gastric aspirate, for identifying newborns who will develop respiratory distress syndrome with a need for surfactant supplementation. Objective: We set out to test whether it was possible to improve the outcome when used in a clinical trial. Methods: We randomly assigned 380 infants born at 24-29 weeks' gestation and supported with nasal continuous positive airway pressure (nCPAP) to receive surfactant guided either by LBC (intervention group) or increasing need for oxygen (control group). The primary outcome was mechanical ventilation or death within 5 days. Secondary outcomes included need for oxygen expressed by arterial to alveolar oxygen tension ratio (a/APO(2)) at the age of 6 h and need for oxygen at day 28. Results: The primary outcomes were equal (25%) in the two groups. The intervention group had higher a/APO(2) than the control group at 6 h, median 0.64 versus 0.52 (p < 0.01), and the subgroup with gestational age 26-29 weeks needed fewer days of oxygen supplementation than the controls, median 2 vs. 9 days (p = 0.01), and fewer infants needed oxygen at day 28 (p = 0.04). Furthermore, there was a tendency in the intervention group towards a shorter duration of nCPAP. Too little or viscose aspirate in 23% of the cases was a limitation of the method. Conclusion: Using LBC test as indicator of lung maturity and early surfactant therapy in very preterm newborns, it is possible to reduce the need for oxygen supplementation. Copyright (C) 2013 S. Karger AG, Basel
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Continuous positive airway pressure
- Nasal CPAP
- Premature infants
- Respiratory distress syndrome
- Pulmonary surfactant
- Lamellar bodies
- Continuous positive airway pressure; Nasal CPAP; Premature infants; Respiratory distress syndrome; Pulmonary surfactant; Lamellar bodies
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Verder, Henrik
-
Ebbesen, Finn
-
Fenger-Gron, Jes ...
-
Henriksen, Tine ...
-
Andreasson, Beng ...
-
Bender, Lars
-
show more...
-
Bertelsen, Aksel
-
Björklund, Lars
-
Dahl, Marianne
-
Esberg, Gitte
-
Eschen, Christia ...
-
Hovring, Marie
-
Kreft, Andreas
-
Kroner, Jorn
-
Lundberg, Fredri ...
-
Pedersen, Pernil ...
-
Reinholdt, Jes
-
Stanchev, Hristo
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
- Articles in the publication
-
Neonatology
- By the university
-
Lund University
-
Linköping University