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  • Verder, HenrikDepartment of Pediatrics, Holbæk Hospital, Holbæk, Denmark (författare)

Early Surfactant Guided by Lamellar Body Counts on Gastric Aspirate in Very Preterm Infants

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2013-07-09
  • S. Karger AG,2013

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:41db50e3-4cf4-411b-9ffc-d794e4b75f62
  • https://lup.lub.lu.se/record/4042620URI
  • https://doi.org/10.1159/000351638DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104751URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: We have developed a rapid method, based on lamellar body counts (LBC) on gastric aspirate, for identifying newborns who will develop respiratory distress syndrome with a need for surfactant supplementation. Objective: We set out to test whether it was possible to improve the outcome when used in a clinical trial. Methods: We randomly assigned 380 infants born at 24-29 weeks' gestation and supported with nasal continuous positive airway pressure (nCPAP) to receive surfactant guided either by LBC (intervention group) or increasing need for oxygen (control group). The primary outcome was mechanical ventilation or death within 5 days. Secondary outcomes included need for oxygen expressed by arterial to alveolar oxygen tension ratio (a/APO(2)) at the age of 6 h and need for oxygen at day 28. Results: The primary outcomes were equal (25%) in the two groups. The intervention group had higher a/APO(2) than the control group at 6 h, median 0.64 versus 0.52 (p < 0.01), and the subgroup with gestational age 26-29 weeks needed fewer days of oxygen supplementation than the controls, median 2 vs. 9 days (p = 0.01), and fewer infants needed oxygen at day 28 (p = 0.04). Furthermore, there was a tendency in the intervention group towards a shorter duration of nCPAP. Too little or viscose aspirate in 23% of the cases was a limitation of the method. Conclusion: Using LBC test as indicator of lung maturity and early surfactant therapy in very preterm newborns, it is possible to reduce the need for oxygen supplementation. Copyright (C) 2013 S. Karger AG, Basel

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ebbesen, FinnDepartment of Pediatrics, Aalborg Hospital, Aalborg, Denmark (författare)
  • Fenger-Gron, JesperDepartment of Pediatrics, Kolding Hospital, Aarhus University, Aarhus, Denmark (författare)
  • Henriksen, Tine BrinkDepartment of Pediatrics, Aarhus University Hospital, Skejby, Denmark (författare)
  • Andreasson, BengtDepartment of Neonatology, Malmö, Sweden (författare)
  • Bender, LarsDepartment of Pediatrics, Aalborg Hospital, Aalborg, Denmark (författare)
  • Bertelsen, AkselDepartment of Pediatrics, Holbæk Hospital, Holbæk, Denmark (författare)
  • Björklund, LarsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Neonatology, Skåne University Hospital, University of Lund, Lund, Sweden(Swepub:lu)pedi-lbj (författare)
  • Dahl, MarianneDepartment of Pediatrics, Odense Hospital, Odense, Denmark (författare)
  • Esberg, GitteDepartment of Pediatrics, Aarhus University Hospital, Skejby, Denmark (författare)
  • Eschen, ChristianDepartment of Pediatrics, Holbæk Hospital, Holbæk, Denmark (författare)
  • Hovring, MarieDepartment of Pediatrics, Holbæk Hospital, Holbæk, Denmark (författare)
  • Kreft, AndreasDepartment of Pediatrics, Sønderborg Hospital, University of South Denmark, Sønderborg, Denmark (författare)
  • Kroner, JornDepartment of Pediatrics, Odense Hospital, Odense, Denmark (författare)
  • Lundberg, FredrikDepartment of Neonatology, Malmö, Sweden(Swepub:liu)frelu52 (författare)
  • Pedersen, Pernilleepartment of Pediatrics, Hvidovre Hospital, Hvidovre, Denmark (författare)
  • Reinholdt, JesDepartment of Neonatology, Rigshospitalet, Copenhagen, Denmark (författare)
  • Stanchev, HristoDepartment of Pediatrics, University of Copenhagen, Næstved, Denmark (författare)
  • Department of Pediatrics, Holbæk Hospital, Holbæk, DenmarkDepartment of Pediatrics, Aalborg Hospital, Aalborg, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Neonatology: S. Karger AG104:2, s. 116-1221661-78001661-7819

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