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Echo time dependenc...
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Führes, TobitUniversity Hospital Erlangen
(författare)
Echo time dependence of biexponential and triexponential intravoxel incoherent motion parameters in the liver
- Artikel/kapitelEngelska2022
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:41e50dc1-e227-4aec-aeb3-e79a1ced95c1
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https://lup.lub.lu.se/record/41e50dc1-e227-4aec-aeb3-e79a1ced95c1URI
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https://doi.org/10.1002/mrm.28996DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Purpose: Intravoxel incoherent motion (IVIM) studies are performed with different acquisition protocols. Comparing them requires knowledge of echo time (TE) dependencies. The TE-dependence of the biexponential perfusion fraction f is well-documented, unlike that of its triexponential counterparts f1 and f2 and the biexponential and triexponential pseudodiffusion coefficients D*, (Formula presented.), and (Formula presented.). The purpose was to investigate the TE-dependence of these parameters and to check whether the triexponential pseudodiffusion compartments are associated with arterial and venous blood. Methods: Fifteen healthy volunteers (19-58 y; mean: 24.7 y) underwent diffusion-weighted imaging of the abdomen with 24 b-values (0.2-800 s/mm2) at TEs of 45, 60, 75, and 90 ms. Regions of interest (ROIs) were manually drawn in the liver. One set of bi- and triexponential IVIM parameters per volunteer and TE was determined. The TE-dependence was assessed with the Kruskal-Wallis test. Results: TE-dependence was observed for f (P <.001), f1 (P =.001), and f2 (P <.001). Their median values at the four measured TEs were: f: 0.198/0.240/0.274/0.359, f1: 0.113/0.139/0.146/0.205, f2: 0.115/0.155/0.182/0.194. D, D*, (Formula presented.), and (Formula presented.) showed no significant TE-dependence. Their values were: diffusion coefficient D (10−4 mm2/s): 9.45/9.63/9.75/9.41, biexponential D* (10−2 mm2/s): 5.26/5.52/6.13/5.82, triexponential (Formula presented.) (10−2 mm2/s): 1.73/2.91/2.25/2.51, triexponential (Formula presented.) (mm2/s): 0.478/1.385/0.616/0.846. Conclusion: f1 and f2 show similar TE-dependence as f, ie, increase with rising TE; an effect that must be accounted for when comparing different studies. The diffusion and pseudodiffusion coefficients might be compared without TE correction. Because of the similar TE-dependence of f1 and f2, the triexponential pseudodiffusion compartments are most probably not associated to venous and arterial blood.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Riexinger, Andreas JulianUniversity Hospital Erlangen
(författare)
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Loh, MartinUniversity Hospital Erlangen
(författare)
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Martin, JanLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ja8663ma
(författare)
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Wetscherek, AndreasRoyal Marsden NHS Foundation Trust
(författare)
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Kuder, Tristan AnselmGerman Cancer Research Centre
(författare)
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Uder, MichaelUniversity Hospital Erlangen
(författare)
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Hensel, BernhardFriedrich-Alexander University Erlangen-Nürnberg
(författare)
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Laun, Frederik BerndUniversity Hospital Erlangen
(författare)
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University Hospital ErlangenFysikalisk kemi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Magnetic Resonance in Medicine: Wiley87:2, s. 859-8710740-31941522-2594
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