L773:1388 1981
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- Raclot, Thierry (author)
A role for hormone-sensitive lipase in the selective mobilization of adipose tissue fatty acids
- Article/chapterEnglish2001
Publisher, publication year, extent ...
- 2001
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:4219dafe-a5aa-4819-bc29-32ef169acb44
- https://lup.lub.lu.se/record/1119096URI
- https://doi.org/10.1016/S1388-1981(01)00119-6DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The mobilization of fatty acids from rat and human fat cells is selective according to molecular structure, and notably carbon atom chain length. This study aimed at examining whether the release of individual fatty acids from triacylglycerols (TAG) by hormone-sensitive lipase (HSL) plays a role in the selectivity of fatty acid mobilization. Recombinant rat and human HSL were incubated with a lipid emulsion. The hydrolysis of 18 individual fatty acids, ranging in chain length from 12 to 24 carbon atoms and in unsaturation degree from 0 to 3 double bond(s), was measured by comparing the composition of non-esterified fatty acids (NEFA) to that of the original TAG. The relative hydrolysis (% in NEFA/% in TAG) differed between fatty acids, being about 5-fold and 3-fold higher for the most(18:1n-7) than for the least (24:0) readily released fatty acid by recombinant rat and human HSL, respectively. Relationships were found between the chain length of fatty acids and their relative hydrolysis. Among 12-24 carbon atom saturated fatty acids, the relative hydrolysis markedly decreased (by about 5- and 3-times for recombinant rat and human HSL, respectively) with increasing chain length. We conclude that fatty acids are selectively released from TAG by HSL according to carbon atom chain length. These data provide insight on the mechanism by which fatty acids are selectively mobilized from fat cells.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- Adipose tissue
- Triacylglycerol
- Lipolysis
- Fatty acid molecular structure
- Lipid emulsion
Added entries (persons, corporate bodies, meetings, titles ...)
- Holm, CeciliaLund University,Lunds universitet,Molekylär endokrinologi,Forskargrupper vid Lunds universitet,Molecular Endocrinology,Lund University Research Groups(Swepub:lu)medk-cho (author)
- Langin, Dominique (author)
- Molekylär endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids1532:1-2, s. 88-961388-1981
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