Search: onr:"swepub:oai:lup.lub.lu.se:4265f07b-206c-49fb-9f4a-6b6e01cfd66f" >
Proton-Pump Inhibit...
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Inghammar, MalinLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Danish Serum Institute, Copenhagen
(author)
Proton-Pump Inhibitor Use and the Risk of Community-Associated Clostridium difficile Infection
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-02-25
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Oxford University Press (OUP),2021
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:4265f07b-206c-49fb-9f4a-6b6e01cfd66f
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https://lup.lub.lu.se/record/4265f07b-206c-49fb-9f4a-6b6e01cfd66fURI
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https://doi.org/10.1093/cid/ciaa1857DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147197361URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Proton-pump inhibitors (PPIs) have been reported to increase the risk of community-associated Clostridium difficile infection (CDI), but the association remains disputed. Methods: A nationwide cohort study among adults in Denmark, 2010-2013, linking register data on C. difficile testing, filled prescriptions, and patient characteristics. All incident episodes of community-associated CDI (ie, positive culture, molecular assay, or toxin test in individuals without previous hospitalization in the prior 12 weeks and without a positive test for C. difficile in the prior 8 weeks) were identified in the Danish National Microbiological Database. Self-controlled case-series analyses were used to estimate incidence rate ratios (IRRs) for community-associated CDI, comparing periods with and without exposure to PPIs. By design, models took fixed confounders such as chronic disease, genetics, and socioeconomic status into account; further, time-varying confounders, including hospital stay and antibiotic and corticosteroid use were adjusted for. Results: 3583 episodes of community-associated CDI were identified, of which 964 occurred during current use of PPIs, 324 occurred 0-6 months after treatment cessation, 123 occurred 6-12 months after treatment cessation, and 2172 occurred during time periods without use of PPIs. The adjusted IRR was 2.03 (95% confidence interval, 1.74-2.36), comparing use of PPI with nonuse. The increased risk remained elevated in later time periods: 1.54 (1.31-1.80) for 0-6 months, 1.24 (1.00-1.53) for 6-12 months after current use. Conclusions: Use of PPIs was associated with moderately increased risk of community-associated CDI. The risk remained elevated up to 1 year after PPI treatment had ended.
Subject headings and genre
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Svanström, HenrikKarolinska Institutet,Karolinska Institute,Danish Serum Institute, Copenhagen
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Voldstedlund, MarianneDanish Serum Institute, Copenhagen
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Melbye, MadsUniversity of Copenhagen,Danish Serum Institute, Copenhagen,Stanford University
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Hviid, AndersDanish Serum Institute, Copenhagen
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Mølbak, KåreDanish Serum Institute, Copenhagen,University of Copenhagen
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Pasternak, BjörnKarolinska Institutet,Karolinska Institute,Danish Serum Institute, Copenhagen(Swepub:lu)extLU-33
(author)
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InfektionsmedicinSektion III
(creator_code:org_t)
Related titles
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In:Clinical Infectious Diseases: Oxford University Press (OUP)72:12, s. 1084-10891058-48381537-6591
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