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Molecular parameter...
Molecular parameters promoting high relaxivity in cluster–nanocarrier magnetic resonance imaging contrast agents
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- Lyons, Trevor (författare)
- Department of Chemistry, Georgetown University, DC, Washington, United States
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- Kekedjian, Chloe (författare)
- Department of Chemistry, Georgetown University, DC, Washington, United States
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- Glaser, Priscilla (författare)
- Department of Chemistry, Georgetown University, DC, Washington, United States
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- Ohlin, C. André (författare)
- Umeå universitet,Kemiska institutionen
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- Van Eldik, Rudi (författare)
- Faculty of Chemistry, Nicolaus Copernicus University, Torun, Poland; Inorganic Chemistry, Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Erlangen, Germany
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- Rodriguez, Olga (författare)
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, DC, Washington, United States
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- Albanese, Christopher (författare)
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, DC, Washington, United States; Department of Radiology, Georgetown University Medical Center, DC, Washington, United States
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- Van Keuren, Edward (författare)
- Department of Physics, Institute for Soft Matter Synthesis and Metrology, Georgetown University, DC, Washington, United States
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- Stoll, Sarah L. (författare)
- Department of Chemistry, Georgetown University, DC, Washington, United States
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(creator_code:org_t)
- 2022-10-25
- 2022
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 14:44, s. 49521-49531
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We have investigated the mechanism of relaxivity for two magnetic resonance imaging contrast agents that both employ a cluster-nanocarrier design. The first system termed Mn8Fe4-coPS comprises the cluster Mn8Fe4O12(L)16(H2O)4 or Mn8Fe4(1) (L = carboxylate) co-polymerized with polystyrene to form ∼75 nm nanobeads. The second system termed Mn3Bpy-PAm used the cluster Mn3(O2CCH3)6(Bpy)2 or Mn3Bpy (2) where Bpy = 2,2′-bipyridine, entrapped in ∼180 nm polyacrylamide nanobeads. Here, we investigate the rate of water exchange of the two clusters, and corresponding cluster-nanocarriers, in order to elucidate the mechanism of relaxivity in the cluster-nanocarrier. Swift-Connick analysis of O-17 NMR was used to determine the water exchange rates of the clusters and cluster-nanocarriers. We found distinct differences in the water exchange rate between Mn8Fe4and Mn8Fe4-coPS, and we utilized these differences to elucidate the nanobead structure. Using the transverse relaxivity from O-17 NMR line widths, we were able to determine the hydration state of the Mn3Bpy (2) cluster as well as Mn3Bpy-PAm. Using these hydration states in the Swift-Connick analysis of O-17 NMR, we found the water exchange rate to be extremely close in value for the cluster Mn3Bpy and cluster-nanocarrier Mn3Bpy-PAm.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- MRI contrast agent
- nanobead
- O-17 NMR
- relaxivity
- water exchange
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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