(WFRF:(Steen Stig)) srt2:(2020-2024)
Sökning: (WFRF:(Steen Stig)) srt2:(2020-2024) > Xenografts Show Sig...
Xenografts Show Signs of Concentric Hypertrophy and Dynamic Left Ventricular Outflow Tract Obstruction after Orthotopic Pig-to-baboon Heart Transplantation
-
- Längin, Matthias (författare)
- University Hospital Munich
-
- Buttgereit, Ines (författare)
- University Hospital Munich
-
- Reichart, Bruno (författare)
- University Hospital Munich
- visa fler...
- visa färre...
- (creator_code:org_t)
- 2023
- 2023
- Engelska.
- Ingår i: Transplantation. - 0041-1337. ; 107:12, s. 328-338
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background. Orthotopic cardiac xenotransplantation has seen substantial advancement in the last years and the initiation of a clinical pilot study is close. However, donor organ overgrowth has been a major hurdle for preclinical experiments, resulting in loss of function and the decease of the recipient. A better understanding of the pathogenesis of organ overgrowth after xenotransplantation is necessary before clinical application. Methods. Hearts from genetically modified (GGTA1-KO, hCD46/hTBM transgenic) juvenile pigs were orthotopically transplanted into male baboons. Group I (control, n = 3) received immunosuppression based on costimulation blockade, group II (growth inhibition, n = 9) was additionally treated with mechanistic target of rapamycin inhibitor, antihypertensive medication, and fast corticoid tapering. Thyroid hormones and insulin-like growth factor 1 were measured before transplantation and before euthanasia, left ventricular (LV) growth was assessed by echocardiography, and hemodynamic data were recorded via a wireless implant. Results. Insulin-like growth factor 1 was higher in baboons than in donor piglets but dropped to porcine levels at the end of the experiments in group I. LV mass increase was 10-fold faster in group I than in group II. This increase was caused by nonphysiological LV wall enlargement. Additionally, pressure gradients between LV and the ascending aorta developed, and signs of dynamic left ventricular outflow tract (LVOT) obstruction appeared. Conclusions. After orthotopic xenotransplantation in baboon recipients, untreated porcine hearts showed rapidly progressing concentric hypertrophy with dynamic LVOT obstruction, mimicking hypertrophic obstructive cardiomyopathy in humans. Antihypertensive and antiproliferative drugs reduced growth rate and inhibited LVOT obstruction, thereby preventing loss of function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta mer i SwePub
- Av författaren/redakt...
- Längin, Matthias
- Buttgereit, Ines
- Reichart, Bruno
- Panelli, Alessan ...
- Radan, Julia
- Mokelke, Maren
- visa fler...
- Bender, Martin
- Michel, Sebastia ...
- Ellgass, Reinhar ...
- Ying, Jiawei
- Fresch, Ann Kath ...
- Mayr, Tanja
- Steen, Stig
- Paskevicius, Aud ...
- Egerer, Stefanie
- Bähr, Andrea
- Kessler, Barbara
- Klymiuk, Nikolai
- Binder, Uli
- Skerra, Arne
- Ledderose, Steph ...
- Müller, Susanna
- Walz, Christoph
- Hagl, Christian
- Wolf, Eckhard
- Ayares, David
- Brenner, Paolo
- Neumann, Elisabe ...
- Abicht, Jan Mich ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Kirurgi
- Artiklar i publikationen
- Transplantation
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
