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Sökning: onr:"swepub:oai:lup.lub.lu.se:42b0188e-310a-45a6-ae7a-c531a79af672" > The performance of ...

  • Brand, Abby L.Washington University in St. Louis (författare)

The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer's disease : a literature review

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-12-27
  • Springer Science and Business Media LLC,2022
  • 1 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:42b0188e-310a-45a6-ae7a-c531a79af672
  • https://lup.lub.lu.se/record/42b0188e-310a-45a6-ae7a-c531a79af672URI
  • https://doi.org/10.1186/s13195-022-01117-1DOI
  • https://gup.ub.gu.se/publication/322161URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:for swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • The extracellular buildup of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer's disease (AD). Detection of Aβ pathology is essential for AD diagnosis and for identifying and recruiting research participants for clinical trials evaluating disease-modifying therapies. Currently, AD diagnoses are usually made by clinical assessments, although detection of AD pathology with positron emission tomography (PET) scans or cerebrospinal fluid (CSF) analysis can be used by specialty clinics. These measures of Aβ aggregation, e.g. plaques, protofibrils, and oligomers, are medically invasive and often only available at specialized medical centers or not covered by medical insurance, and PET scans are costly. Therefore, a major goal in recent years has been to identify blood-based biomarkers that can accurately detect AD pathology with cost-effective, minimally invasive procedures.To assess the performance of plasma Aβ assays in predicting amyloid burden in the central nervous system (CNS), this review compares twenty-one different manuscripts that used measurements of 42 and 40 amino acid-long Aβ (Aβ42 and Aβ40) in plasma to predict CNS amyloid status. Methodologies that quantitate Aβ42 and 40 peptides in blood via immunoassay or immunoprecipitation-mass spectrometry (IP-MS) were considered, and their ability to distinguish participants with amyloidosis compared to amyloid PET and CSF Aβ measures as reference standards was evaluated. Recent studies indicate that some IP-MS assays perform well in accurately and precisely measuring Aβ and detecting brain amyloid aggregates.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lawler, Paige E.Washington University in St. Louis (författare)
  • Bollinger, James G.Washington University in St. Louis (författare)
  • Li, YanWashington University in St. Louis (författare)
  • Schindler, Suzanne E.Washington University in St. Louis (författare)
  • Li, MelodyWashington University in St. Louis (författare)
  • Lopez, SamirWashington University in St. Louis (författare)
  • Ovod, VitaliyWashington University in St. Louis (författare)
  • Nakamura, AkinoriNagoya University,National Center for Geriatrics and Gerontology (författare)
  • Shaw, Leslie M.University of Pennsylvania (författare)
  • Zetterberg, HenrikGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (författare)
  • Hansson, OskarLund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Klinisk minnesforskning,Neurobiology,Lund University Research Groups,Clinical Memory Research,Skåne University Hospital(Swepub:lu)mphy-ohn (författare)
  • Bateman, Randall J.Washington University in St. Louis (författare)
  • Washington University in St. LouisNagoya University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Alzheimer's Research & Therapy: Springer Science and Business Media LLC14:1, s. 195-1951758-9193

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