A Central Role for GRB10 in Regulation of Islet Function in Man.

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Prokopenko, Inga (author)

A Central Role for GRB10 in Regulation of Islet Function in Man.

Article/chapterEnglish2014

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2014-04-03
Public Library of Science (PLoS),2014
electronicrdacarrier

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:42b2dd7a-fd3f-420c-a3d6-30e14a9d4ec1
https://lup.lub.lu.se/record/4430862URI
https://doi.org/10.1371/journal.pgen.1004235DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-222122URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father.

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Poon, WennyLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-wyp (author)
Mägi, Reedik (author)
Prasad, RashmiLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-rpa (author)
Salehi, S AlbertLund University,Lunds universitet,Islet cell physiology,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)farm-sal (author)
Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal (author)
Osmark, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)medk-pos (author)
Bouatia-Naji, Nabila (author)
Wierup, NilsLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)mphy-nwi (author)
Fall, ToveUppsala universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)tovfa878 (author)
Stančáková, Alena (author)
Barker, Adam (author)
Lagou, Vasiliki (author)
Osmond, Clive (author)
Xie, Weijia (author)
Lahti, Jari (author)
Jackson, Anne U (author)
Cheng, Yu-Ching (author)
Liu, Jie (author)
O'Connell, Jeffrey R (author)
Blomstedt, Paul A (author)
Fadista, JoaoLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-jft (author)
Alkayyali, SamiLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-sai (author)
Dayeh, TasnimLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics(Swepub:lu)med-tmd (author)
Ahlqvist, EmmaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)infl-eah (author)
Taneera, JalalLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)stem-jta (author)
Lecoeur, Cecile (author)
Kumar, Ashish (author)
Hansson, OlaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)medk-oha (author)
Hansson, Karin BLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-knh (author)
F Voight, BenjaminLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-bf_ (author)
Kang, Hyun Min (author)
Levy-Marchal, Claire (author)
Vatin, Vincent (author)
Palotie, AarnoLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-aop (author)
Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)anncsyva (author)
Mari, Andrea (author)
Weedon, Michael N (author)
Loos, Ruth J F (author)
Ong, Ken K (author)
Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
Isomaa, Bo (author)
Tuomi, TiinamaijaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)ti8736tu (author)
Wareham, Nicholas J (author)
Stumvoll, Michael (author)
Widen, Elisabeth (author)
Lakka, Timo A (author)
Langenberg, Claudia (author)
Tönjes, Anke (author)
Rauramaa, Rainer (author)
Kuusisto, Johanna (author)
Frayling, Timothy M (author)
Froguel, Philippe (author)
Walker, Mark (author)
Eriksson, Johan G (author)
Ling, CharlotteLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics(Swepub:lu)endo-cl0 (author)
Kovacs, Peter (author)
Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England(Swepub:uu)ering425 (author)
McCarthy, Mark I (author)
Shuldiner, Alan R (author)
Silver, Kristi D (author)
Laakso, Markku (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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By the author/editor: Prokopenko, Inga; Poon, Wenny; Mägi, Reedik; Prasad, Rashmi; Salehi, S Albert; Almgren, Peter; show more...; Osmark, Peter; Bouatia-Naji, Na ...; Wierup, Nils; Fall, Tove; Stančáková, Alen ...; Barker, Adam; Lagou, Vasiliki; Osmond, Clive; Xie, Weijia; Lahti, Jari; Jackson, Anne U; Cheng, Yu-Ching; Liu, Jie; O'Connell, Jeffr ...; Blomstedt, Paul ...; Fadista, Joao; Alkayyali, Sami; Dayeh, Tasnim; Ahlqvist, Emma; Taneera, Jalal; Lecoeur, Cecile; Kumar, Ashish; Hansson, Ola; Hansson, Karin B; F Voight, Benjam ...; Kang, Hyun Min; Levy-Marchal, Cl ...; Vatin, Vincent; Palotie, Aarno; Syvänen, Ann-Chr ...; Mari, Andrea; Weedon, Michael ...; Loos, Ruth J F; Ong, Ken K; Nilsson, Peter; Isomaa, Bo; Tuomi, Tiinamaij ...; Wareham, Nichola ...; Stumvoll, Michae ...; Widen, Elisabeth; Lakka, Timo A; Langenberg, Clau ...; Tönjes, Anke; Rauramaa, Rainer; Kuusisto, Johann ...; Frayling, Timoth ...; Froguel, Philipp ...; Walker, Mark; Eriksson, Johan ...; Ling, Charlotte; Kovacs, Peter; Ingelsson, Erik; McCarthy, Mark I; Shuldiner, Alan ...; Silver, Kristi D; Laakso, Markku; Groop, Leif; Lyssenko, Valeri ...; show less...

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