id:"swepub:oai:lup.lub.lu.se:42b889de-6a9b-4567-b72c-253d20080bcf"
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- Holm Nielsen, S.Technical University of Denmark,Nordic Bioscience AS (author)
A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2018-08-28
- Wiley,2019
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:42b889de-6a9b-4567-b72c-253d20080bcf
- https://lup.lub.lu.se/record/42b889de-6a9b-4567-b72c-253d20080bcfURI
- https://doi.org/10.1111/joim.12819DOI
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- Language:English
- Summary in:English
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- Objective: Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-mediated COL1 biomarker, C1M, was associated with cardiovascular events, cardiovascular mortality and all-cause mortality in a large prospective cohort of patients with known atherosclerosis. Methods: Serum from 787 patients who underwent a carotid endarterectomy was included. Circulating levels of C1M were measured in serum. A total of 473 patients were followed for 6 years after surgery. Associations between C1M and incidence of cardiovascular events, cardiovascular mortality and all-cause mortality were assessed by Kaplan–Meier curves and Cox regression analysis. Results: A total of 101 (21.4%) patients suffered from nonfatal cardiovascular events during the follow-up period, and 64 (13.5%) patients died. Of these, 39 (60.9%) died from cardiovascular diseases. Patients with C1M levels above the median were significantly associated with cardiovascular events, cardiovascular mortality and all-cause mortality (P < 0.001, P = 0.004 and P < 0.001, respectively). C1M was included in the final model for prediction of cardiovascular events (HR 2.15, 95% CI 1.40–3.32, P = 0.001), cardiovascular mortality (HR 2.20, 95% CI 1.07–4.51, P = 0.031) and all-cause mortality (HR 2.98 95% CI 1.67–5.33, P = < 0.001). Conclusions: In patients with atherosclerotic carotid lesions, high levels of C1M predicted cardiovascular events, cardiovascular mortality and all-cause mortality. These findings emphasize the importance of remodelling mechanisms in atherosclerosis that are now becoming more and more explored.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- atherosclerosis
- biomarkers
- collagen
- extracellular matrix
- inflammation
Added entries (persons, corporate bodies, meetings, titles ...)
- Tengryd, C.Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)med-ctg (author)
- Edsfeldt, A.Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-aet (author)
- Brix, S.Technical University of Denmark (author)
- Genovese, F.Nordic Bioscience AS (author)
- Bengtsson, E.Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - matrix och inflammation i ateroskleros,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Matrix and Inflammation in Atherosclerosis(Swepub:lu)medf-eb0 (author)
- Karsdal, M.Nordic Bioscience AS (author)
- Leeming, D. J.Nordic Bioscience AS (author)
- Nilsson, J.Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-jni (author)
- Goncalves, I.Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Translational Studies,Skåne University Hospital(Swepub:lu)medf-igo (author)
- Technical University of DenmarkNordic Bioscience AS (creator_code:org_t)
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- In:Journal of Internal Medicine: Wiley285:1, s. 118-1230954-6820
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