Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

• There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

susceptibility

familial aggregation

multiple myeloma

MGUS

lymphoma

Waldenstrom's macroglobulinemia

lymphoplasmacytic lymphoma

leukemia

chronic lymphocytic

Hodgkin's lymphoma

non-Hodgkin's lymphoma

immune-related

autoimmune disease

rheumatoid arthritis

monoclonal

B-cell lymphocytosis

Publikations- och innehållstyp

for (ämneskategori)

ref (ämneskategori)