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Genome-wide interac...
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Li, YafangDartmouth College
(author)
Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2017-10-20
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Oxford University Press (OUP),2018
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11 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:4354b0eb-88ad-4ca4-a85c-bd22fa04a78e
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https://lup.lub.lu.se/record/4354b0eb-88ad-4ca4-a85c-bd22fa04a78eURI
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https://doi.org/10.1093/carcin/bgx113DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142386URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never- versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13 336 non-small cell lung cancer cases. Candidate SNPs with P-value <0.001 were further analyzed using a standard case-control interaction analysis including 13 970 controls. The significant SNPs with P-value <3.5 × 10-5 (correcting for multiple tests) from the case-control analysis in the discovery stage were further validated using an independent replication dataset comprising 5377 controls and 3054 non-small cell lung cancer cases. We further stratified the analysis by histological subtypes. Two novel SNPs, rs6441286 and rs17723637, were identified for overall lung cancer risk. The interaction odds ratio and meta-analysis P-value for these two SNPs were 1.24 with 6.96 × 10-7 and 1.37 with 3.49 × 10-7, respectively. In addition, interaction of smoking with rs4751674 was identified in squamous cell lung carcinoma with an odds ratio of 0.58 and P-value of 8.12 × 10-7. This study is by far the largest genome-wide SNP-smoking interaction analysis reported for lung cancer. The three identified novel SNPs provide potential candidate biomarkers for lung cancer risk screening and intervention. The results from our study reinforce that gene-smoking interactions play important roles in the etiology of lung cancer and account for part of the missing heritability of this disease.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Xiao, XiangjunDartmouth College
(author)
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Han, YounghunDartmouth College
(author)
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Gorlova, OlgaDartmouth College
(author)
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Qian, DavidDartmouth College
(author)
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Leighl, NatashaUniversity of Toronto
(author)
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Johansen, Jakob S.Gentofte Hospital
(author)
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Barnett, MattFred Hutchinson Cancer Research Center
(author)
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Chen, ChuFred Hutchinson Cancer Research Center,Imperial College London,Vanderbilt University,University of Milan,Harvard University
(author)
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Goodman, GarySwedish Medical Center
(author)
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Cox, AngelaUniversity of Sheffield
(author)
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Taylor, FionaUniversity of Sheffield
(author)
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Woll, PenellaUniversity of Sheffield
(author)
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Wichmann, H. ErichHelmholtz Zentrum München
(author)
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Manz, JudithHelmholtz Zentrum München
(author)
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Muley, ThomasGerman Center for Lung Research (DZL),University Hospital Heidelberg
(author)
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Risch, AngelaUniversity of Salzburg,German Center for Lung Research (DZL),University Hospital Heidelberg
(author)
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Rosenberger, AlbertUniversity of Göttingen
(author)
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Arnold, Susanne M.University of Kentucky Medical Center
(author)
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Haura, Eric B.H. Lee Moffitt Cancer Center & Research Institute
(author)
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Bolca, CiprianNational Institute of Pneumology M. Nasta
(author)
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Holcatova, IvanaUniversity of Ostrava
(author)
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Janout, VladimirUniversity of Ostrava
(author)
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Kontic, MilicaUniversity of Belgrade
(author)
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Lissowska, JolantaThe Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
(author)
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Mukeria, AnushN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
(author)
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Ognjanovic, SimonaInternational Organization for Cancer Prevention and Research
(author)
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Orlowski, Tadeusz M.National Tuberculosis and Lung Diseases Research Institute
(author)
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Scelo, GhislaineInternational Agency for Research on Cancer, World Health Organization
(author)
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Swiatkowska, BeataNofer Institute of Occupational Medicine
(author)
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Zaridze, DavidN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
(author)
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Bakke, PerUniversity of Bergen
(author)
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Skaug, VidarNational Institute of Occupational Health, Norway
(author)
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Zienolddiny, ShanbehNational Institute of Occupational Health, Norway
(author)
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Duell, Eric J.Catalan Institute of Oncology
(author)
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Butler, Lesley M.University of Pittsburgh Cancer Institute
(author)
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Houlston, RichardInstitute of Cancer Research London
(author)
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Artigas, María SolerUniversity of Leicester,Glenfield Hospital
(author)
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Grankvist, KjellUmeå universitet,Umeå University,Klinisk kemi(Swepub:umu)kjgr0002
(author)
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Johansson, MikaelUmeå universitet,Umeå University,Onkologi(Swepub:umu)mijo0025
(author)
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Shepherd, Frances A.Princess Margaret Hospital University of Toronto
(author)
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Marcus, Michael W.University of Liverpool
(author)
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Brunnström, HansLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-hsb
(author)
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Manjer, JonasLund University,Lunds universitet,Skåne University Hospital(Swepub:lu)smi-jma
(author)
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Melander, OlleLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)endo-ome
(author)
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Muller, David C.Imperial College London
(author)
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Overvad, KimAarhus University
(author)
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Trichopoulou, AntoniaNational and Kapodistrian University of Athens
(author)
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Tumino, RosarioCancer Research and Prevention Institute (ISPO)
(author)
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Liu, GeoffreyPrincess Margaret Hospital University of Toronto
(author)
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Bojesen, Stig E.Gentofte Hospital,University of Copenhagen
(author)
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Wu, XifengUniversity of Texas
(author)
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Marchand, Loic LeUniversity of Hawaii Cancer Center
(author)
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Albanes, DemetriosNational Cancer Institute, USA
(author)
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Bickeböller, HeikeUniversity Medical Center Göttingen
(author)
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Aldrich, Melinda C.Vanderbilt University
(author)
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Bush, William S.Case Western Reserve University
(author)
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Tardon, AdoninaUniversity of Oviedo
(author)
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Rennert, GadTechnion - Israel Institute of Technology
(author)
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Dawn Teare, M.University of Sheffield
(author)
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Field, John K.University of Liverpool
(author)
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Kiemeney, Lambertus A.Radboud University Nijmegen
(author)
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Lazarus, PhilipWashington State University
(author)
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Haugen, AageNational Institute of Occupational Health, Norway
(author)
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Lam, StephenBC Cancer Research Centre
(author)
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Schabath, Matthew B.H. Lee Moffitt Cancer Center & Research Institute
(author)
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Andrew, Angeline S.Dartmouth College
(author)
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Bertazzi, Pier AlbertoUniversity of Milan
(author)
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Pesatori, Angela C.University of Milan
(author)
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Christiani, David C.Harvard University
(author)
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Caporaso, NeilNational Cancer Institute, USA
(author)
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization
(author)
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McKay, James D.International Agency for Research on Cancer, World Health Organization
(author)
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Brennan, PaulInternational Agency for Research on Cancer, World Health Organization
(author)
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Hung, Rayjean J.University of Toronto
(author)
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Amos, Christopher I.Dartmouth College
(author)
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Dartmouth CollegeUniversity of Toronto
(creator_code:org_t)
Related titles
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In:Carcinogenesis: Oxford University Press (OUP)39:3, s. 336-3460143-33341460-2180
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- By the author/editor
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Li, Yafang
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Xiao, Xiangjun
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Han, Younghun
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Gorlova, Olga
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Qian, David
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Leighl, Natasha
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Johansen, Jakob ...
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Barnett, Matt
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Chen, Chu
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Goodman, Gary
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Cox, Angela
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Taylor, Fiona
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Woll, Penella
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Wichmann, H. Eri ...
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Manz, Judith
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Muley, Thomas
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Risch, Angela
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Rosenberger, Alb ...
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Arnold, Susanne ...
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Haura, Eric B.
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Bolca, Ciprian
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Holcatova, Ivana
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Janout, Vladimir
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Kontic, Milica
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Lissowska, Jolan ...
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Mukeria, Anush
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Ognjanovic, Simo ...
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Orlowski, Tadeus ...
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Scelo, Ghislaine
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Swiatkowska, Bea ...
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Zaridze, David
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Bakke, Per
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Skaug, Vidar
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Zienolddiny, Sha ...
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Duell, Eric J.
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Butler, Lesley M ...
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Houlston, Richar ...
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Artigas, María S ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Shepherd, France ...
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Marcus, Michael ...
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Brunnström, Hans
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Manjer, Jonas
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Melander, Olle
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Muller, David C.
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Overvad, Kim
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Trichopoulou, An ...
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Tumino, Rosario
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Liu, Geoffrey
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Bojesen, Stig E.
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Wu, Xifeng
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Marchand, Loic L ...
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Albanes, Demetri ...
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Bickeböller, Hei ...
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Aldrich, Melinda ...
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Bush, William S.
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Tardon, Adonina
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Rennert, Gad
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Dawn Teare, M.
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Field, John K.
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Kiemeney, Lamber ...
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Lazarus, Philip
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Haugen, Aage
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Lam, Stephen
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Schabath, Matthe ...
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Andrew, Angeline ...
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Bertazzi, Pier A ...
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Pesatori, Angela ...
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Christiani, Davi ...
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Caporaso, Neil
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Johansson, Matti ...
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McKay, James D.
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Brennan, Paul
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Hung, Rayjean J.
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Amos, Christophe ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Carcinogenesis
- By the university
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Lund University
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Umeå University