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Eosinophils—from cr...
Eosinophils—from cradle to grave
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- Jesenak, Milos (författare)
- University Hospital Martin
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- Diamant, Zuzana (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Simon, Dagmar (författare)
- Bern University Hospital
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- Tufvesson, Ellen (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Tornbladinstitutet,Lungfysiologi och biomarkörer,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Tornblad Institute,Lung physiology and biomarkers
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- Seys, Sven F. (författare)
- Catholic University of Leuven
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- Mukherjee, Manali (författare)
- McMaster University
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- Lacy, Paige (författare)
- University of Alberta
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- Vijverberg, Susanne (författare)
- University of Amsterdam
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- Slisz, Tomas (författare)
- Charles University in Prague
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- Sediva, Anna (författare)
- University Hospital Motol
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- Simon, Hans Uwe (författare)
- University of Bern
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- Striz, Ilja (författare)
- Institute for Clinical and Experimental Medicine (IKEM)
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- Plevkova, Jana (författare)
- Comenius University
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- Schwarze, Jurgen (författare)
- University of Edinburgh
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- Kosturiak, Radovan (författare)
- Comenius University
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- Alexis, Neil E. (författare)
- University of North Carolina
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- Untersmayr, Eva (författare)
- Medical University of Vienna
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- Vasakova, Martina Koziar (författare)
- Charles University in Prague
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- Knol, Edward (författare)
- University Medical Center Utrecht
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- Koenderman, Leo (författare)
- University Medical Center Utrecht
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(creator_code:org_t)
- 2023
- 2023
- Engelska 26 s.
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Ingår i: Allergy: European Journal of Allergy and Clinical Immunology. - 0105-4538. ; 78:12, s. 3077-3102
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual's eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- allergic diseases
- biologics
- biomarker
- COVID-19
- eosinophils
- non-allergic diseases
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Jesenak, Milos
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Diamant, Zuzana
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Simon, Dagmar
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Tufvesson, Ellen
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Seys, Sven F.
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Mukherjee, Manal ...
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visa fler...
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Lacy, Paige
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Vijverberg, Susa ...
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Slisz, Tomas
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Sediva, Anna
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Simon, Hans Uwe
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Striz, Ilja
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Plevkova, Jana
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Schwarze, Jurgen
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Kosturiak, Radov ...
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Alexis, Neil E.
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Untersmayr, Eva
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Vasakova, Martin ...
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Knol, Edward
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Koenderman, Leo
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Lunds universitet