WFRF:(Almgren P)
Search: WFRF:(Almgren P) > (2005-2009) > Association testing...
- 17 of 18
- Previous record
- Next record
- To hitlist
- Winckler, W (author)
Association testing of variants in the hepatocyte nuclear factor 4 alpha gene with risk of type 2 diabetes in 7,883 people
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- American Diabetes Association,2005
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:43dc42a0-3a18-46a7-a7a3-9197a8a1f209
- https://lup.lub.lu.se/record/250624URI
- https://doi.org/10.2337/diabetes.54.3.886DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Two recent publications reported association of common polymorphisms in the P2 promoter of hepatocyte nuclear factor 4alpha (HNF4alpha) (the MODY1 gene) with risk for type 2 diabetes. We attempted to reproduce this putative association by genotyping 11 single nucleotide polymorphism (SNPs) spanning the HNF4a coding region and the P2 promoter in >3,400 patients and control subjects from Sweden, Finland, and Canada. One SNP that was consistently associated in the two previous reports (rs1884613, in the P2 promoter region) also trended in the same direction in our sample, albeit with a lower estimated odds ratio (OR) of 1.11 (P = 0.05, one-tailed). We genotyped this SNP (rs1884613) in an additional 4,400 subjects from North America and Poland. In this sample, the association was not confirmed and trended in the opposite direction (OR 0.88). Meta-analysis of our combined sample of 7,883 people (three times larger than the two initial reports combined) yielded an OR of 0.97 (P = 0.27). Finally, we provide an updated analysis of haplotype structure in the region to guide any further investigation of common variation in HNF4alpha. Although our combined results fail to replicate the previously reported association of common variants in HNF4alpha with risk for type 2 diabetes, we cannot exclude an effect smaller than that originally proposed, heterogeneity among samples, variation in as-yet-unmeasured genotypic or environmental modifiers, or true association secondary to linkage disequilibrium (LD) with as-yet-undiscovered variant(s) in the region.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Graham, R R (author)
- de Bakker, P I W (author)
- Sun, M (author)
- Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal (author)
- Tuomi, T (author)
- Gaudet, D (author)
- Hudson, T J (author)
- Ardlie, K G (author)
- Daly, M J (author)
- Hirschhorn, J N (author)
- Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
- Altshuler, D (author)
- Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Diabetes: American Diabetes Association54:3, s. 886-8921939-327X0012-1797
Internet link
- 17 of 18
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Winckler, W
- Graham, R R
- de Bakker, P I W
- Sun, M
- Almgren, Peter
- Tuomi, T
- show more...
- Gaudet, D
- Hudson, T J
- Ardlie, K G
- Daly, M J
- Hirschhorn, J N
- Groop, Leif
- Altshuler, D
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Diabetes
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
