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Weight change in mi...
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Christakoudi, SofiaKing's College London,Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Kings Coll London, MRC Ctr Transplantat, London, England.
(författare)
Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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LIBRIS-ID:oai:lup.lub.lu.se:4411a3d7-d562-40d9-b506-97c05465ab72
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https://lup.lub.lu.se/record/4411a3d7-d562-40d9-b506-97c05465ab72URI
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https://doi.org/10.1002/ijc.33339DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177088URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438950URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (±0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pagoni, PanagiotaUniversity of Ioannina,University of Bristol,Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.;Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.
(författare)
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Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
(författare)
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Cross, Amanda J.Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.
(författare)
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Tzoulaki, IoannaImperial College London,University of Ioannina,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.
(författare)
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Muller, David C.Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.
(författare)
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
(författare)
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Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
(författare)
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Murphy, NeilInternational Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
(författare)
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Dossus, LaureInternational Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
(författare)
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Turzanski Fortner, ReneeGerman Cancer Research Centre,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
(författare)
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Agudo, AntonioIDIBELL LHospitalet de Llobregat, Unit Nutr & Canc, Canc Epidemiol Res Program, Catalan Inst Oncol, Barcelona, Spain.,Catalan Institute of Oncology
(författare)
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Overvad, KimAarhus University,Aalborg University Hospital,Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.
(författare)
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Perez-Cornago, AuroraUniversity of Oxford,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
(författare)
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Key, Timothy J.University of Oxford,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
(författare)
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Brennan, PaulInternational Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
(författare)
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.
(författare)
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Tjønneland, AnneDanish Cancer Society,Danish Canc Soc Res Ctr, Copenhagen, Denmark.
(författare)
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Halkjær, JytteDanish Cancer Society,Danish Canc Soc Res Ctr, Copenhagen, Denmark.
(författare)
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Boutron-Ruault, Marie ChristineUniversity of Paris-Saclay,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.
(författare)
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Artaud, FannyUniversity of Paris-Saclay,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.
(författare)
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Severi, GianlucaUniversity of Florence,University of Paris-Saclay,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.;Univ Florence, Dept Stat Comp Sci & Applicat G Parenti DISIA, Florence, Italy.
(författare)
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Kaaks, RudolfGerman Cancer Research Centre,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
(författare)
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Schulze, Matthias B.University of Potsdam,German Institute of Human Nutrition,German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.;Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany.
(författare)
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Bergmann, Manuela M.German Institute of Human Nutrition,German Inst Human Nutr Potsdam Rehbrucke DIfE, Dept Epidemiol, Nuthetal, Germany.
(författare)
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Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO),ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Inst Canc Res Prevent & Clin Network, Florence, Italy.
(författare)
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Grioni, SaraIstituto Nazionale dei Tumori,Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Milan, Italy.
(författare)
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Simeon, VittorioUniversity of Campania Luigi Vanvitelli,Univ LVanvitelli, Dept Mental Phys Hlth & Prevent Med, Naples, Italy.
(författare)
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Tumino, RosarioProvincial Health Authority (ASP) Ragusa,Prov Hlth Author ASP Ragusa, Canc Registry & Histopathol Dept, Ragusa, Italy.
(författare)
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Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin,Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy.;Ctr Canc Prevent CPO, Turin, Italy.
(författare)
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Skeie, GuriUiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.
(författare)
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Rylander, CharlottaUiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.
(författare)
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Borch, Kristin BenjaminsenUiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.
(författare)
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Quirós, J. RamónPubl Hlth Directorate, Asturias, Spain.
(författare)
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Rodriguez-Barranco, MiguelCIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),Escuela Andaluza Salud Publ EASP, Granada, Spain.;Inst Invest Biosanitaria ibs GRANADA, Granada, Spain.;Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
(författare)
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Chirlaque, Maria DoloresMurcia Regional Health Council,University of Murcia,CIBER Epidemiology and Public Health (CIBERESP),Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain.
(författare)
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Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP),Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;Navarra Publ Hlth Inst, Pamplona, Spain.;Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain.(Swepub:lu)extLU-05
(författare)
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Amiano, PilarBiodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP),Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;BioDonostia Researach Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain.
(författare)
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Drake, IsabelLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diabetes - Cardiovascular Disease,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden.(Swepub:lu)med-ihm
(författare)
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Stocks, TanjaLund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Lund, Sweden.(Swepub:lu)med-tss
(författare)
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Häggström, ChristelUppsala universitet,Umeå universitet,Uppsala University,Umeå University,Enheten för biobanksforskning,Department of Surgical Science, Uppsala University, Uppsala, Sweden,Endokrinkirurgi,Umeå Univ, Dept Biobank Res, Umeå, Sweden.(Swepub:uu)chrha650
(författare)
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Harlid, SophiaUmeå universitet,Umeå University,Onkologi,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.(Swepub:umu)soha0105
(författare)
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Ellingjord-Dale, MereteImperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.
(författare)
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Riboli, ElioImperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.
(författare)
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Tsilidis, Konstantinos K.Imperial College London,University of Ioannina,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.
(författare)
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King's College LondonImperial College London
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Cancer: Wiley148:7, s. 1637-16510020-71361097-0215
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Christakoudi, So ...
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Pagoni, Panagiot ...
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Ferrari, Pietro
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Cross, Amanda J.
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Tzoulaki, Ioanna
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Muller, David C.
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visa fler...
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Weiderpass, Elis ...
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Freisling, Heinz
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Murphy, Neil
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Dossus, Laure
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Turzanski Fortne ...
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Agudo, Antonio
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Overvad, Kim
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Perez-Cornago, A ...
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Key, Timothy J.
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Brennan, Paul
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Johansson, Matti ...
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Tjønneland, Anne
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Halkjær, Jytte
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Boutron-Ruault, ...
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Artaud, Fanny
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Severi, Gianluca
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Kaaks, Rudolf
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Schulze, Matthia ...
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Bergmann, Manuel ...
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Masala, Giovanna
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Grioni, Sara
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Simeon, Vittorio
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Tumino, Rosario
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Sacerdote, Carlo ...
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Skeie, Guri
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Rylander, Charlo ...
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Borch, Kristin B ...
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Quirós, J. Ramón
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Rodriguez-Barran ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Amiano, Pilar
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Drake, Isabel
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Stocks, Tanja
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Häggström, Chris ...
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Harlid, Sophia
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Ellingjord-Dale, ...
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Riboli, Elio
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Tsilidis, Konsta ...
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