Search: onr:"swepub:oai:lup.lub.lu.se:44513f7b-2ec2-40d6-8ec0-514890aa1305" >
Hepatopancreatoduod...
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D'Souza, Melroy A.Karolinska Institutet
(author)
Hepatopancreatoduodenectomy –a controversial treatment for bile duct and gallbladder cancer from a European perspective
- Article/chapterEnglish2020
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LIBRIS-ID:oai:lup.lub.lu.se:44513f7b-2ec2-40d6-8ec0-514890aa1305
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https://lup.lub.lu.se/record/44513f7b-2ec2-40d6-8ec0-514890aa1305URI
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https://doi.org/10.1016/j.hpb.2019.12.008DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144837311URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Hepatopancreatoduodenectomy (HPD) is an aggressive operation for treatment of advanced bile duct and gallbladder cancer associated with high perioperative morbidity and mortality, and uncertain oncological benefit in terms of survival. Few reports on HPD from Western centers exist. The purpose of this study was to evaluate safety and efficacy for HPD in European centers. Method: Members of the European-African HepatoPancreatoBiliary Association were invited to report all consecutive patients operated with HPD for bile duct or gallbladder cancer between January 2003 and January 2018. The patient and tumor characteristics, perioperative and survival outcomes were analyzed. Results: In total, 66 patients from 19 European centers were included in the analysis. 90-day mortality rate was 17% and 13% for bile duct and gallbladder cancer respectively. All factors predictive of perioperative mortality were patient and disease-specific. The three-year overall survival excluding 90-day mortality was 80% for bile duct and 30% for gallbladder cancer (P = 0.013). In multivariable analysis R0-resection had a significant impact on overall survival. Conclusion: HPD, although being associated with substantial perioperative mortality, can offer a survival benefit in patient subgroups with bile duct cancer and gallbladder cancer. To achieve negative resection margins is paramount for an improved survival outcome.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Valdimarsson, Valentinus T.Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)va4706va
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Campagnaro, TommasoUniversity Hospital Verona
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Cauchy, FrancoisBeaujon Hospital
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Chatzizacharias, Nikolaos A.New Queen Elizabeth Hospital
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D'Hondt, Mathieu
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Dasari, BobbyNew Queen Elizabeth Hospital
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Ferrero, AlessandroMauriziano Hospital, Turin
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Franken, Lotte C.Academic Medical Center of University of Amsterdam (AMC)
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Fusai, GiuseppeGreat Ormond Street Hospital
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Guglielmi, AlfredoUniversity Hospital Verona
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Hagendoorn, JeroenUniversity Medical Center Utrecht
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Hidalgo Salinas, CamilaGreat Ormond Street Hospital
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Hoogwater, Frederik J.H.University Medical Center Groningen
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Jorba, RosaHospital Joan XXIII
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Karanjia, Nariman
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Knoefel, Wolfram T.University Hospital of Düsseldorf
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Kron, PhilippLeeds Teaching Hospitals NHS Trust
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Lahiri, Rajiv
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Langella, SerenaMauriziano Hospital, Turin
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Le Roy, BertrandBeaujon Hospital
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Lehwald-Tywuschik, NadjaUniversity Hospital of Düsseldorf
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Lesurtel, MickaelClaude Bernard University Lyon 1
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Li, JunUniversity Medical Center Hamburg-Eppendorf
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Lodge, J. Peter A.Leeds Teaching Hospitals NHS Trust
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Martinou, Erini
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Molenaar, Izaak Q.University Medical Center Utrecht
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Nikov, AndrejThe Military University Hospital Prague
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Poves, IgnasiHospital del Mar Medical Research Institute
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Rassam, FadiAcademic Medical Center of University of Amsterdam (AMC)
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Russolillo, NadiaMauriziano Hospital, Turin
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Soubrane, OlivierBeaujon Hospital
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Stättner, StefanMedical University of Innsbruck
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van Dam, Ronald M.Yukioka Hospital
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van Gulik, Thomas M.Academic Medical Center of University of Amsterdam (AMC)
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Serrablo, AlejandroMiguel Servet University Hospital
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Gallagher, Tom M.St Vincent's University Hospital
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Sturesson, ChristianKarolinska Institutet(Swepub:lu)med-cst
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Karolinska InstitutetKirurgi, Lund
(creator_code:org_t)
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E-AHPBA scientific and research committee
Related titles
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In:HPB: Elsevier BV22:9, s. 1339-13481365-182X
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In:HPB : the official journal of the International Hepato Pancreato Biliary Association: Elsevier BV22:9, s. 1339-13481477-2574
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D'Souza, Melroy ...
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Valdimarsson, Va ...
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Campagnaro, Tomm ...
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Cauchy, Francois
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Chatzizacharias, ...
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D'Hondt, Mathieu
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Dasari, Bobby
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Ferrero, Alessan ...
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Franken, Lotte C ...
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Fusai, Giuseppe
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Guglielmi, Alfre ...
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Hagendoorn, Jero ...
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Hidalgo Salinas, ...
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Hoogwater, Frede ...
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Jorba, Rosa
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Karanjia, Narima ...
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Knoefel, Wolfram ...
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Kron, Philipp
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Lahiri, Rajiv
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Langella, Serena
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Le Roy, Bertrand
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Lehwald-Tywuschi ...
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Lesurtel, Mickae ...
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Li, Jun
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Martinou, Erini
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Molenaar, Izaak ...
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Nikov, Andrej
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Poves, Ignasi
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Rassam, Fadi
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Russolillo, Nadi ...
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Stättner, Stefan
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