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Impact of ischaemic...
Impact of ischaemic heart disease severity and age on risk of cardiovascular outcome in diabetes patients in Sweden : A nationwide observational study
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- Jernberg, Tomas (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Lindholm, Daniel P, 1982- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Clin Res Ctr, Sweden
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- Hasvold, Lars Pål (author)
- AstraZeneca Nord, Med Dept, Oslo, Norway
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- Svennblad, Bodil (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Ortopedi,Uppsala Clin Res Ctr, Sweden
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- Bodegård, Johan (author)
- AstraZeneca Nord, Med Dept, Oslo, Norway
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- Sundell Andersson, Karolina (author)
- AstraZeneca R&D, Global Med Affairs CardioVasc Renal & Metab, Gothenburg, Sweden,AstraZeneca RandD, Sweden
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- Thuresson, Marcus (author)
- Statisticon, Stockholm, Sweden
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- Erlinge, David (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Lund Univ, Clin Sci, Lund, Sweden
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- Janzon, Magnus (author)
- Linköpings universitet,Linköping University,Linkopings Univ, Cardiol, Linkoping, Sweden,Avdelningen för hälso- och sjukvårdsanalys,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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(creator_code:org_t)
- 2019-04-03
- 2019
- English.
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In: BMJ Open. - : BMJ. - 2044-6055. ; 9:4
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Abstract
Subject headings
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- Objectives To compare short-term cardiovascular (CV) outcome in type 2 diabetes (T2D) patients without ischaemic heart disease (IHD), with IHD but no prior myocardial infarction (MI), and those with prior MI; and assess the impact on risk of age when initiating first-time glucose-lowering drug (GLD). Design Cohort study linking morbidity, mortality and medication data from Swedish national registries. Participants First-time users of GLD during 2007-2016. Outcomes Predicted cumulative incidence for the CV outcome (MI, stroke and CV mortality) was estimated. A Cox model was developed where age at GLD start and CV risk was modelled. Results 260 070 first-time GLD users were included, 221 226 (85%) had no IHD, 16 294 (6%) had stable IHD-prior MI and 22 550 (9%) had IHD+MI. T2D patients without IHD had a lower risk of CV outcome compared with the IHD populations (±prior MI), (3-year incidence 4.78% vs 5.85% and 8.04%). The difference in CV outcome was primarily driven by a relative greater MI risk among the IHD patients. For T2D patients without IHD, an almost linear association between age at start of GLD and relative risk was observed, whereas in IHD patients, the younger (<60 years) patients had a relative greater risk compared with older patients. Conclusions T2D patients without IHD had a lower risk of the CV outcome compared with the T2D populations with IHD, primarily driven by a greater risk of MI. For T2D patients without IHD, an almost linear association between age at start of GLD and relative risk was observed, whereas in IHD patients, the younger patients had a relative greater risk compared with older patients. Our findings suggest that intense risk prevention should be the key strategy in the management of T2D patients, especially for younger patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiac epidemiology
- coronary heart disease
- general diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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