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Long-term weight ch...
Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC)
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Lahmann, PH (författare)
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Schulz, M (författare)
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Hoffmann, K (författare)
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visa fler...
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Boeing, H (författare)
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Tjonneland, A (författare)
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Olsen, A (författare)
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Overvad, K (författare)
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Key, TJ (författare)
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Allen, NE (författare)
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Khaw, KT (författare)
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Bingham, S (författare)
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- Berglund, Göran (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Wirfält, Elisabet (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Berrino, F (författare)
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Krogh, V (författare)
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Trichopoulou, A (författare)
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Lagiou, P (författare)
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Trichopoulos, D (författare)
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Kaaks, R (författare)
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Riboli, E (författare)
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(creator_code:org_t)
- 2005-08-30
- 2005
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 93:5, s. 582-589
- Relaterad länk:
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http://dx.doi.org/10...
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We examined prospectively the association between weight change during adulthood and breast cancer risk, using data on 1358 incident cases that developed during 5.8 years of follow-up among 40 429 premenopausal and 57 923 postmenopausal women from six European countries, taking part in the European prospective investigation into cancer and nutrition study. Multivariate Cox regression models were used to calculate hazard ratios according to weight change ( kg), defined as the weight difference between age at enrolment and age 20 adjusted for other risk factors. Changes in weight were not associated with premenopausal breast cancer risk. In postmenopausal women, weight gain was positively associated with breast cancer risk only among noncurrent hormone replacement therapy (HRT) users (P-trend <= 0.0002). Compared to women with a stable weight ( 72 kg), the relative risk for women who gained 15 - 20 kg was 1.50 (95% confidence interval (CI) 1.06 - 2.13). The pooled RR per weight gain increment of 5 kg was 1.08 ( 95% CI 1.04 - 1.12). Weight gain was not associated with breast cancer risk in current HRT users, although, overall, these women experienced a much higher risk of breast cancer compared with nonusers. Our findings suggest that large adult weight gain was a significant predictor of breast cancer in postmenopausal women not taking exogenous hormones.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- breast neoplasm
- weight history
- obesity
- replacement therapy
- hormone
- weight gain
- menopausal status
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lahmann, PH
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Schulz, M
-
Hoffmann, K
-
Boeing, H
-
Tjonneland, A
-
Olsen, A
-
visa fler...
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Overvad, K
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Key, TJ
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Allen, NE
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Khaw, KT
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Bingham, S
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Berglund, Göran
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Wirfält, Elisabe ...
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Berrino, F
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Krogh, V
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Trichopoulou, A
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Lagiou, P
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Trichopoulos, D
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Kaaks, R
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Riboli, E
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visa färre...
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