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The behavioral vari...
The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
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- Singleton, E. H. (författare)
- Vrije Universiteit Amsterdam
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- Pijnenburg, Y. A.L. (författare)
- Vrije Universiteit Amsterdam
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- Gami-Patel, P. (författare)
- Vrije Universiteit Amsterdam
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- Boon, B. D.C. (författare)
- Vrije Universiteit Amsterdam
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- Bouwman, F. (författare)
- Vrije Universiteit Amsterdam
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- Papma, J. M. (författare)
- Erasmus University Medical Center
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- Seelaar, H. (författare)
- Erasmus University Medical Center
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- Scheltens, P. (författare)
- Vrije Universiteit Amsterdam
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- Grinberg, L. T. (författare)
- University of California, San Francisco
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- Spina, S. (författare)
- University of California, San Francisco
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- Nana, A. L. (författare)
- University of California, San Francisco
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- Rabinovici, G. D. (författare)
- University of California, San Francisco
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- Seeley, W. W. (författare)
- University of California, San Francisco
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- Ossenkoppele, R. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam
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- Dijkstra, A. A. (författare)
- Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2022-01-20
- 2022
- Engelska.
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Ingår i: Alzheimer's Research and Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 14:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://alzres.biome...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer’s disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal dementia (bvFTD) and several psychiatric diseases. Here, we assessed whether these specific neuronal populations show a selective loss in bvAD. Methods: VENs and GABA receptor subunit theta (GABRQ)-immunoreactive pyramidal neurons of the anterior cingulate cortex (ACC) were quantified in post-mortem tissue of patients with bvAD (n = 9) and compared to typical AD (tAD, n = 6), bvFTD due to frontotemporal lobar degeneration based on TDP-43 pathology (FTLD, n = 18) and controls (n = 13) using ANCOVAs adjusted for age and Bonferroni corrected. In addition, ratios of VENs and GABRQ-immunoreactive (GABRQ-ir) pyramidal neurons over all Layer 5 neurons were compared between groups to correct for overall Layer 5 neuronal loss. Results: The number of VENs or GABRQ-ir neurons did not differ significantly between bvAD (VENs: 26.0 ± 15.3, GABRQ-ir pyramidal: 260.4 ± 87.1) and tAD (VENs: 32.0 ± 18.1, p = 1.00, GABRQ-ir pyramidal: 349.8 ± 109.6, p = 0.38) and controls (VENs: 33.5 ± 20.3, p = 1.00, GABRQ-ir pyramidal: 339.4 ± 95.9, p = 0.37). Compared to bvFTD, patients with bvAD showed significantly more GABRQ-ir pyramidal neurons (bvFTD: 140.5 ± 82.658, p = 0.01) and no significant differences in number of VENs (bvFTD: 10.9 ± 13.8, p = 0.13). Results were similar when assessing the number of VENs and GABRQ-ir relative to all neurons of Layer 5. Discussion: VENs and phylogenetically related neurons did not show a selective loss in the ACC in patients with bvAD. Our results suggest that, unlike in bvFTD, the clinical presentation in bvAD may not be related to the loss of VENs and related neurons in the ACC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer’s disease
- Behavior
- Frontotemporal dementia
- Pathology
- Von Economo Neurons
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Singleton, E. H.
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Pijnenburg, Y. A ...
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Gami-Patel, P.
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Boon, B. D.C.
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Bouwman, F.
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Papma, J. M.
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visa fler...
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Seelaar, H.
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Scheltens, P.
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Grinberg, L. T.
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Spina, S.
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Nana, A. L.
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Rabinovici, G. D ...
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Seeley, W. W.
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Ossenkoppele, R.
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Dijkstra, A. A.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Alzheimer's Rese ...
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Lunds universitet