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Dietary intake of t...
Dietary intake of trans fatty acids and breast cancer risk in 9 European countries
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- Matta, Michèle (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
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- Huybrechts, Inge (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
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- Biessy, Carine (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
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- Casagrande, Corinne (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France,Department of Public Health, Aarhus University, Aarhus, Denmark
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- Yammine, Sahar (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
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- Fournier, Agnès (author)
- University of Paris-Saclay,CESP “Health Across Generations”, INSERM, Univ Paris-Sud, UVSQ, Univ Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
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- Olsen, Karina Standahl (author)
- UiT The Arctic University of Norway, Tromsø,Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Lukic, Marco (author)
- UiT The Arctic University of Norway, Tromsø,Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Gram, Inger Torhild (author)
- UiT The Arctic University of Norway, Tromsø,Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Ardanaz, Eva (author)
- CIBER Epidemiology and Public Health (CIBERESP),Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Sánchez, Maria José (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Dossus, Laure (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
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- Fortner, Renée T. (author)
- Division of Cancer Epidemiology, German Cancer Research Centre (DFKZ), Heidelberg, Germany
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- Srour, Bernard (author)
- Division of Cancer Epidemiology, German Cancer Research Centre (DFKZ), Heidelberg, Germany
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- Jannasch, Franziska (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; NutriAct - Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany,German Center for Diabetes Research,NutriAct - Competence Cluster Nutrition Research Berlin-Potsdam
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
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- Amiano, Pilar (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, BioDonostia Research Institute, Donostia-San Sebastian, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Agudo, Antonio (author)
- Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain,L'Hospitalet de Llobregat, Barcelona
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- Colorado-Yohar, Sandra (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia,CIBER Epidemiology and Public Health (CIBERESP),University of Antioquia
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- Quirós, J. Ramón (author)
- Public Health Directorate, Asturias, Spain
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- Tumino, Rosario (author)
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
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- Panico, Salvatore (author)
- Dipartimento Di Medicina Clinica e Chirurgia, Federici II University, Naples, Italy
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- Masala, Giovanna (author)
- Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy
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- Pala, Valeria (author)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, di Milano Via Venezian, 1, Milan, Italy
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- Sacerdote, Carlotta (author)
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Via Santena 7, Turin, Italy
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Copenhagen University, Copenhagen, Denmark,University of Copenhagen
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- Olsen, Anja (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Aarhus University, Aarhus, Denmark,Danish Cancer Society
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- Dahm, Christina C. (author)
- Aarhus University
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- Rosendahl, Ann H. (author)
- Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Clinical Sciences Lund, Oncology, Lund University and Skåne University Hospital, Lund, Sweden
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- Borgquist, Signe (author)
- Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Clinical Sciences Lund, Oncology, Lund University and Skåne University Hospital, Lund, Sweden; Department of Oncology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark,Aarhus University Hospital,Aarhus University
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- Wennberg, Maria, 1974- (author)
- Umeå universitet,Umeå University,Avdelningen för hållbar hälsa
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- Heath, Alicia K. (author)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
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- Aune, Dagfinn (author)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Ullevål, Oslo, Norway,Bjørknes University College,Imperial College London
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- Schmidt, Julie (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization,Office of the Director, International Agency for Research on Cancer, Lyon, France
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- Chajes, Veronique (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
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- Gunter, Marc J. (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
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- Murphy, Neil (author)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
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(creator_code:org_t)
- 2021-03-30
- 2021
- English.
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In: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 19:1
- Related links:
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https://bmcmedicine....
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone receptor-defined molecular subtypes, menopausal status, and body size have rarely been conducted. Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between dietary intakes of TFAs (industrial trans fatty acids [ITFAs] and ruminant trans fatty acids [RTFAs]) and breast cancer risk among 318,607 women. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for other breast cancer risk factors. Results: After a median follow-up of 8.1 years, 13,241 breast cancer cases occurred. In the multivariable-adjusted model, higher total ITFA intake was associated with elevated breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06–1.23; P trend = 0.001). A similar positive association was found between intake of elaidic acid, the predominant ITFA, and breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06–1.23; P trend = 0.001). Intake of total RTFAs was also associated with higher breast cancer risk (HR for highest vs lowest quintile, 1.09, 95% CI 1.01–1.17; P trend = 0.015). For individual RTFAs, we found positive associations with breast cancer risk for dietary intakes of two strongly correlated fatty acids (Spearman correlation r = 0.77), conjugated linoleic acid (HR for highest vs lowest quintile, 1.11, 95% CI 1.03–1.20; P trend = 0.001) and palmitelaidic acid (HR for highest vs lowest quintile, 1.08, 95% CI 1.01–1.16; P trend = 0.028). Similar associations were found for total ITFAs and RTFAs with breast cancer risk according to menopausal status, body mass index, and breast cancer subtypes. Conclusions: These results support the hypothesis that higher dietary intakes of ITFAs, in particular elaidic acid, are associated with elevated breast cancer risk. Due to the high correlation between conjugated linoleic acid and palmitelaidic acid, we were unable to disentangle the positive associations found for these fatty acids with breast cancer risk. Further mechanistic studies are needed to identify biological pathways that may underlie these associations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Breast cancer
- Diet
- Industrial trans fatty acids
- Ruminant trans fatty acids
- Breast cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Matta, Michèle
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Huybrechts, Inge
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Biessy, Carine
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Casagrande, Cori ...
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Yammine, Sahar
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Fournier, Agnès
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show more...
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Olsen, Karina St ...
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Lukic, Marco
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Gram, Inger Torh ...
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Ardanaz, Eva
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Sánchez, Maria J ...
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Dossus, Laure
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Fortner, Renée T ...
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Srour, Bernard
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Jannasch, Franzi ...
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Schulze, Matthia ...
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Amiano, Pilar
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Agudo, Antonio
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Colorado-Yohar, ...
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Quirós, J. Ramón
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Tumino, Rosario
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Panico, Salvator ...
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Masala, Giovanna
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Pala, Valeria
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Sacerdote, Carlo ...
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Tjønneland, Anne
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Olsen, Anja
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Dahm, Christina ...
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Rosendahl, Ann H ...
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Borgquist, Signe
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Wennberg, Maria, ...
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Heath, Alicia K.
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Aune, Dagfinn
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Schmidt, Julie
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Weiderpass, Elis ...
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Chajes, Veroniqu ...
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Gunter, Marc J.
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Murphy, Neil
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and Health Sciences
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BMC Medicine
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Lund University
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Umeå University