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  • Norby, Faye LUniversity of Minnesota (author)

Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation : The AFGen Consortium

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-03-21
  • Public Library of Science (PLoS),2016

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:45446237-3fa5-49b1-89b2-b219aeae1263
  • https://lup.lub.lu.se/record/45446237-3fa5-49b1-89b2-b219aeae1263URI
  • https://doi.org/10.1371/journal.pone.0151932DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.METHODS: We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score.RESULTS: During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98-1.03); 0.98 (0.96-1.01); 0.98 (0.95-1.02); 0.99 (0.97-1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97-1.03); 1.01 (0.99-1.04).CONCLUSIONS: In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Eryd, Samuel AdamssonLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)med-sed (author)
  • Niemeijer, Maartje NErasmus University Rotterdam (author)
  • Rose, Lynda MHarvard University (author)
  • Smith, Albert VUniversity of Iceland (author)
  • Yin, XiaoyanBoston University (author)
  • Agarwal, Sunil KIcahn School of Medicine at Mount Sinai (author)
  • Arking, Dan EJohns Hopkins University (author)
  • Chasman, Daniel LHarvard University (author)
  • Chen, Lin YUniversity of Minnesota (author)
  • Eijgelsheim, MarkErasmus University Rotterdam (author)
  • Engström, GunnarLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)smi-gen (author)
  • Franco, Oscar H (author)
  • Heeringa, Jan (author)
  • Hindy, GeorgeLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)med-ghu (author)
  • Hofman, Albert (author)
  • Lutsey, Pamela L (author)
  • Magnani, Jared W (author)
  • McManus, David D (author)
  • Orho-Melander, MarjuLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-mor (author)
  • Pankow, James S (author)
  • Rukh, GullLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)med-grk (author)
  • Schulz, Christina-AlexandraLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)med-csc (author)
  • Uitterlinden, André G (author)
  • Albert, Christine M (author)
  • Benjamin, Emelia J (author)
  • Gudnason, Vilmundur (author)
  • Smith, GustavLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Institutionen för kliniska vetenskaper, Malmö,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Malmö(Swepub:lu)med-gvs (author)
  • Stricker, Bruno H C (author)
  • Alonso, Alvaro (author)
  • University of MinnesotaInstitutionen för kliniska vetenskaper, Malmö (creator_code:org_t)

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  • In:PLoS ONE: Public Library of Science (PLoS)11:31932-6203

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