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Adverse event manag...
Adverse event management in patients with relapsed and refractory multiple myeloma taking pomalidomide plus low-dose dexamethasone : A pooled analysis
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- Moreau, Philippe (author)
- Nantes University Hospital
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- Dimopoulos, Meletios A. (author)
- National and Kapodistrian University of Athens
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- Richardson, Paul G (author)
- Dana-Farber Cancer Institute
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- Siegel, David S. (author)
- Hackensack University Medical Center
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- Cavo, Michele (author)
- University of Bologna
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- Corradini, Paolo (author)
- University of Milan
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- Weisel, Katja C. (author)
- University Hospital of Tubingen
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- Delforge, Michel (author)
- University Hospitals Leuven
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- O'Gorman, Peter (author)
- Mater Misericordiae University Hospital
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- Song, Kevin (author)
- Vancouver General Hospital
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- Chen, Christine (author)
- Princess Margaret Hospital University of Toronto
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- Bahlis, Nizar (author)
- University of Calgary
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- Oriol, Albert (author)
- Hospital Universitari Germans Trias i Pujol
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- Hansson, Markus (author)
- Lund University,Lunds universitet,Myelomgruppen,Forskargrupper vid Lunds universitet,Myeloma research group,Lund University Research Groups
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- Kaiser, Martin (author)
- Royal Marsden Hospital, Sutton
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- Anttila, Pekka (author)
- Helsinki University Central Hospital
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- Raymakers, Reinier (author)
- University Medical Center Utrecht
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- Joao, Cristina (author)
- NOVA University Lisbon
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- Cook, Gordon (author)
- St James's University Hospital
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- Sternas, Lars (author)
- Celgene Corporation
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- Biyukov, Tsvetan (author)
- Celgene International Sàrl
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- Slaughter, Ana (author)
- Celgene International Sàrl
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- Hong, Kevin (author)
- Celgene Corporation
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- Herring, Jennifer (author)
- Celgene Corporation
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- Yu, Xin (author)
- Celgene Corporation
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- Zaki, Mohamed H. (author)
- Celgene Corporation
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- San Miguel, Jesus (author)
- University of Navarra
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(creator_code:org_t)
- 2017-06-14
- 2017
- English 8 s.
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In: European Journal of Haematology. - : Wiley. - 0902-4441. ; 99:3, s. 199-206
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objectives: Heavily pretreated patients with relapsed and refractory multiple myeloma are susceptible to treatment-related adverse events (AEs). Managing AEs are important to ensure patients continue therapy long enough to receive the best clinical benefit. Data from the MM-002, MM-003, and MM-010 trials were pooled to further characterize the safety profile of pomalidomide plus low-dose dexamethasone and AE management. Methods: This analysis included 1088 patients who received ≥ 2 prior therapies, including lenalidomide and bortezomib, and progressed ≤ 60 days of last therapy. Patients received 28-day cycles of pomalidomide 4 mg/day on days 1-21 and low-dose dexamethasone 40 mg (20 mg if aged > 75 years) weekly until disease progression or unacceptable toxicity. Thromboprophylaxis was required. Results: The most common grade 3/4 AEs were neutropenia (56.2%), anemia (32.3%), and thrombocytopenia (25.8%), which occurred within the first few cycles of treatment. Grade 3/4 infections occurred in 33.7% patients, of whom 13.9% had pneumonia, and 40.3% had neutropenia. Pomalidomide dose reductions or interruptions were reported in 24.2% and 66.0% of patients, respectively. AEs were managed by dose modifications and/or supportive care. Conclusions: Pomalidomide plus low-dose dexamethasone showed an acceptable safety profile, and AEs were well managed according to study protocols and established guidelines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- dexamethasone
- pomalidomide
- pooled analysis
- relapsed and refractory multiple myeloma
- safety
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Moreau, Philippe
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Dimopoulos, Mele ...
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Richardson, Paul ...
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Siegel, David S.
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Cavo, Michele
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Corradini, Paolo
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show more...
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Weisel, Katja C.
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Delforge, Michel
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O'Gorman, Peter
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Song, Kevin
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Chen, Christine
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Bahlis, Nizar
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Oriol, Albert
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Hansson, Markus
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Kaiser, Martin
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Anttila, Pekka
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Raymakers, Reini ...
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Joao, Cristina
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Cook, Gordon
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Sternas, Lars
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Biyukov, Tsvetan
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Slaughter, Ana
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Hong, Kevin
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Herring, Jennife ...
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Yu, Xin
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Zaki, Mohamed H.
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San Miguel, Jesu ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Journal ...
- By the university
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Lund University