Weight and body mass index in relation to irradiated volume and to overall survival in patients with oropharyngeal cancer: a retrospective cohort study

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Ottosson, Sandra,1981-Umeå universitet,Öron- näs- och halssjukdomar (author)

Weight and body mass index in relation to irradiated volume and to overall survival in patients with oropharyngeal cancer: a retrospective cohort study

Article/chapterEnglish2014

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2014
electronicrdacarrier

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LIBRIS-ID:oai:lup.lub.lu.se:46422bdc-dd0c-4da5-9b50-626ee8d85700
https://lup.lub.lu.se/record/4590686URI
https://doi.org/10.1186/1748-717X-9-160DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231121URI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82489URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Background: Weight loss is a common problem in patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN) treated with radiotherapy (RT). The aims of the present study were to determine if treated volume (TV), as a measure of the radiation dose burden, can predict weight loss in patients with oropharyngeal cancer and to analyze weight loss and body mass index (BMI) in the same patient group in relation to 5-year overall survival. Methods: The ARTSCAN trial is a prospective, randomized, multicenter trial in patients with SCCHN. Nutritional data from the ARTSCAN trial were analyzed retrospectively using univariate and multivariate statistical methods based on information on percentage weight loss from the start of RT up to five months after the termination of RT (study cohort 1, n = 232) and information on patients' BMI at the start of RT (study cohort 2, n = 203). TV was defined as the volume of the patient receiving at least 95% of the prescribed dose. TV64.6 (Gy) encompasses macroscopic tumor and TV43.7 (Gy) elective lymph nodes of the neck. Results: TV64.6 Gy and TV43.7 Gy were both significantly correlated with higher weight loss up to five months after the termination of RT in study cohort 1 (p < 0.001 for both). BMI at the start of RT was shown to be a prognostic factor for 5-year overall survival in study cohort 2 but weight loss was not. The hazard ratios and 95% confidence intervals were 3.78 (1.46-9.75) and 2.57 (1.43-4.62) in patients with underweight and normal weight, respectively. Conclusions: TV can predict weight loss during RT in patients with oropharyngeal cancer regardless of clinical stage. A high BMI (>25 kg/m(2)) at the start of RT is positively associated with survival in patients with oropharyngeal cancer.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oto-rhino-laryngologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Otorhinolaryngology hsv//eng
Oropharyngeal cancer
Treated volume
Weight loss
Body mass index
Survival
Oropharyngeal cancer
Oto-Rhino-Laryngology

Added entries (persons, corporate bodies, meetings, titles ...)

Söderström, KarinUmeå universitet,Onkologi(Swepub:umu)kansom97 (author)
Kjellén, ElisabethLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ekj (author)
Nilsson, PerLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)rafy-per (author)
Zackrisson, BjörnUmeå universitet,Onkologi(Swepub:umu)bjza0002 (author)
Laurell, GöranUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)gorla772 (author)
Umeå universitetÖron- näs- och halssjukdomar (creator_code:org_t)

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