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  • Ward, Heather A.Imperial College London,University of Paris-Saclay,Catalan Institute of Oncology (author)

Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2018-10-18
  • Springer Science and Business Media LLC,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:464e9036-09d2-4a17-84c2-4c1ca9314bfe
  • https://lup.lub.lu.se/record/464e9036-09d2-4a17-84c2-4c1ca9314bfeURI
  • https://doi.org/10.1038/s41430-018-0271-2DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162675URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141556470URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confounding. Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 416,746 individuals from 10 countries completed demographic and dietary questionnaires at recruitment. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident lung cancer (n = 3731) risk relative to haem iron, non-haem iron, and total dietary iron intake. A corresponding analysis was conducted among a nested subset of 800 lung cancer cases and 1489 matched controls for whom serum cotinine was available. Results: Haem iron was associated with lung cancer risk, including after adjustment for details of smoking history (time since quitting, number of cigarettes per day): as a continuous variable (HR per 0.3 mg/1000 kcal 1.03, 95% CI 1.00–1.07), and in the highest versus lowest quintile (HR 1.16, 95% CI 1.02–1.32; trend across quintiles: P = 0.035). In contrast, non-haem iron intake was related inversely with lung cancer risk; however, this association attenuated after adjustment for smoking history. Additional adjustment for serum cotinine did not considerably alter the associations detected in the nested case–control subset. Conclusions: Greater haem iron intake may be modestly associated with lung cancer risk.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Whitman, JuliaImperial College London (author)
  • Muller, David C.Imperial College London (author)
  • Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization (author)
  • Jakszyn, PaulaCatalan Institute of Oncology (author)
  • Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø,University of Helsinki (author)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (author)
  • Fanidi, AnouarInternational Agency for Research on Cancer, World Health Organization (author)
  • Vermeulen, RoelUtrecht University (author)
  • Tjønneland, AnneDanish Cancer Society (author)
  • Hansen, LouiseDanish Cancer Society (author)
  • Dahm, Christina C.Aarhus University (author)
  • Overvad, KimAarhus University (author)
  • Severi, GianlucaUniversity of Paris-Saclay (author)
  • Boutron-Ruault, Marie ChristineUniversity of Paris-Saclay (author)
  • Affret, AurélieUniversity of Paris-Saclay,Imperial College London (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Fortner, ReneeGerman Cancer Research Centre (author)
  • Boeing, HeinerGerman Institute of Human Nutrition (author)
  • Trichopoulou, AntoniaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (author)
  • La Vecchia, CarloUniversity of Milan,Hellenic Health Foundation, Athens (author)
  • Kotanidou, AnastasiaHellenic Health Foundation, Athens,National and Kapodistrian University of Athens (author)
  • Berrino, FrancoIstituto Nazionale dei Tumori (author)
  • Krogh, VittorioIstituto Nazionale dei Tumori (author)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (author)
  • Ricceri, FulvioUniversity of Turin (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Bueno-de-Mesquita, H. BasNational Institute for Public Health and the Environment (RIVM),Imperial College London (author)
  • Peeters, Petra H.Imperial College London,University Medical Center Utrecht (author)
  • Nøst, Therese HaugdahlUiT The Arctic University of Norway, Tromsø (author)
  • Sandanger, Torkjel M.UiT The Arctic University of Norway, Tromsø (author)
  • Quirós, Jose Ramón (author)
  • Agudo, AntonioCatalan Institute of Oncology (author)
  • Rodríguez-Barranco, MiguelCIBER Epidemiology and Public Health (CIBERESP),University of Granada (author)
  • Larrañaga, NereaCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Huerta, Jose MariaCIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council (author)
  • Ardanaz, EvaMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05 (author)
  • Drake, IsabelLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-ihm (author)
  • Brunnström, HansLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups(Swepub:lu)med-hsb (author)
  • Johansson, MikaelUmeå universitet,Umeå University,Onkologi(Swepub:umu)mijo0025 (author)
  • Grankvist, KjellUmeå universitet,Umeå University,Klinisk kemi(Swepub:umu)kjgr0002 (author)
  • Travis, Ruth C.University of Oxford (author)
  • Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization (author)
  • Stepien, MagdalenaInternational Agency for Research on Cancer, World Health Organization (author)
  • Merritt, Melissa A.Imperial College London (author)
  • Riboli, ElioImperial College London (author)
  • Cross, Amanda J.Imperial College London (author)
  • Imperial College LondonUniversity of Paris-Saclay (creator_code:org_t)

Related titles

  • In:European Journal of Clinical Nutrition: Springer Science and Business Media LLC8:73, s. 1122-11320954-30071476-5640

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