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  • Wray, Selina (author)

Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012-08-27
  • Public Library of Science (PLoS),2012
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:4665e44d-6196-47f9-a47a-7cd7820ab69e
  • https://lup.lub.lu.se/record/3147136URI
  • https://doi.org/10.1371/journal.pone.0043099DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Self, Matthew (author)
  • Lewis, Patrick A. (author)
  • Taanman, Jan-Willem (author)
  • Ryan, Natalie S. (author)
  • Mahoney, Colin J. (author)
  • Liang, Yuying (author)
  • Devine, Michael J. (author)
  • Sheerin, Una-Marie (author)
  • Houlden, Henry (author)
  • Morris, Huw R. (author)
  • Healy, Daniel (author)
  • Marti-Masso, Jose-Felix (author)
  • Preza, Elisavet (author)
  • Barker, Suzanne (author)
  • Sutherland, Margaret (author)
  • Corriveau, Roderick A. (author)
  • D'Andrea, Michael (author)
  • Schapira, Anthony H. V. (author)
  • Uitti, Ryan J. (author)
  • Guttman, Mark (author)
  • Opala, Grzegorz (author)
  • Jasinska-Myga, Barbara (author)
  • Puschmann, AndreasLund University,Lunds universitet,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-aps (author)
  • Nilsson, ChristerLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-cni (author)
  • Espay, Alberto J. (author)
  • Slawek, Jaroslaw (author)
  • Gutmann, Ludwig (author)
  • Boeve, Bradley F. (author)
  • Boylan, Kevin (author)
  • Stoessl, A. Jon (author)
  • Ross, Owen A. (author)
  • Maragakis, Nicholas J. (author)
  • Van Gerpen, Jay (author)
  • Gerstenhaber, Melissa (author)
  • Gwinn, Katrina (author)
  • Dawson, Ted M. (author)
  • Isacson, Ole (author)
  • Marder, Karen S. (author)
  • Clark, Lorraine N. (author)
  • Przedborski, Serge E. (author)
  • Finkbeiner, Steven (author)
  • Rothstein, Jeffrey D. (author)
  • Wszolek, Zbigniew K. (author)
  • Rossor, Martin N. (author)
  • Hardy, John (author)
  • Sektion IVInstitutionen för kliniska vetenskaper, Lund (creator_code:org_t)

Related titles

  • In:PLoS ONE: Public Library of Science (PLoS)7:81932-6203

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