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  • Enattah, Nabil Sabri (author)

Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Elsevier BV,2007

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:471a168a-80e5-4e0c-8c90-b825d386b3c5
  • https://lup.lub.lu.se/record/689709URI
  • https://doi.org/10.1086/520705DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • A single-nucleotide variant, C/T-13910, located 14 kb upstream of the lactase gene (LCT), has been shown to be completely correlated with lactase persistence (LP) in northern Europeans. Here, we analyzed the background of the alleles carrying the critical variant in 1,611 DNA samples from 37 populations. Our data show that the T-13910 variant is found on two different, highly divergent haplotype backgrounds in the global populations. The first is the most common LP haplotype (LP H98) present in all populations analyzed, whereas the others (LP H8-H12), which originate from the same ancestral allelic haplotype, are found in geographically restricted populations living west of the Urals and north of the Caucasus. The global distribution pattern of LP T-13910 H98 supports the Caucasian origin of this allele. Age estimates based on different mathematical models show that the common LP T-13910 H98 allele (similar to 5,000-12,000 years old) is relatively older than the other geographically restricted LP alleles (similar to 1,400-3,000 years old). Our data about global allelic haplotypes of the lactose-tolerance variant imply that the T-13910 allele has been independently introduced more than once and that there is a still-ongoing process of convergent evolution of the LP alleles in humans.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Trudeau, Aimee (author)
  • Pimenoff, Ville (author)
  • Maiuri, Luigi (author)
  • Auricchio, Salvatore (author)
  • Greco, Luigi (author)
  • Rossi, Mauro (author)
  • Lentze, Michael (author)
  • Seo, J. K. (author)
  • Rahgozar, Soheila (author)
  • Khalil, Insaf (author)
  • Alifrangis, Michael (author)
  • Natah, Sirajedin (author)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
  • Shaat, NaelLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-nsh (author)
  • Kozlov, Andrew (author)
  • Verschubskaya, Galina (author)
  • Comas, David (author)
  • Bulayeva, Kazima (author)
  • Mehdi, S. Qasim (author)
  • Terwilliger, Joseph D. (author)
  • Sahi, Timo (author)
  • Savilahti, Erkki (author)
  • Perola, Markus (author)
  • Sajantila, Antti (author)
  • Jaervelae, Irma (author)
  • Peltonen, Leena (author)
  • Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:American Journal of Human Genetics: Elsevier BV81:3, s. 615-6250002-9297

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