id:"swepub:oai:lup.lub.lu.se:48496c52-a10a-4f73-ac79-e364ef09fb54"
Search: id:"swepub:oai:lup.lub.lu.se:48496c52-a10a-4f73-ac79-e364ef09fb54" > Human fetal basal f...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Nilsson, O GLund University (author)
Human fetal basal forebrain neurons grafted to the denervated rat hippocampus produce an organotypic cholinergic reinnervation pattern
- Article/chapterEnglish1988
Publisher, publication year, extent ...
- Elsevier BV,1988
- 6 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:48496c52-a10a-4f73-ac79-e364ef09fb54
- https://lup.lub.lu.se/record/48496c52-a10a-4f73-ac79-e364ef09fb54URI
- https://doi.org/10.1016/0006-8993(88)90363-0DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The septal/diagonal band (SDB) area, obtained from a 9- to 10-week-old aborted human fetus, was grafted to the hippocampal formation of adult, immunosuppressed rats subjected to an aspirative lesion of the fimbria-fornix. Nineteen weeks after transplantation, microscopical analysis revealed large, partly acetylcholinesterase (AChE)-positive grafts in the hippocampus in 3 of the 5 recipients. The AChE-positive grafts gave rise to a reinnervation of the host hippocampus and an AChE-positive lamination of the different hippocampal subfields with the same characteristics as the normal septum-derived innervation. Immunological evaluation of host sera revealed that all rats were immunized by the graft. This indicates that grafted human cholinergic SDB neurons can respond to or interact with factors that regulate and guide the innervation of the rat hippocampus.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Acetylcholinesterase
- Animals
- Cholinergic Fibers
- Female
- Frontal Lobe
- Gestational Age
- Graft Survival
- Hippocampus
- Humans
- Neuronal Plasticity
- Rats
- Rats, Inbred Strains
- Transplantation, Heterologous
Added entries (persons, corporate bodies, meetings, titles ...)
- Brundin, PLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)mphy-pbr (author)
- Widner, HStockholm University(Swepub:lu)mphy-hwi (author)
- Strecker, R ELund University (author)
- Björklund, ALund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups(Swepub:lu)mphy-abj (author)
- Lund UniversityInstitutionen för experimentell medicinsk vetenskap (creator_code:org_t)
Related titles
- In:Brain Research: Elsevier BV456:1, s. 8-1930006-8993
Internet link
Find in a library
- Brain Research (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Nilsson, O G
- Brundin, P
- Widner, H
- Strecker, R E
- Björklund, A
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Brain Research
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
