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Association of Circ...
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Georgakis, Marios K.University Hospital Munich,Ludwig-Maximilian University of Munich
(författare)
Association of Circulating Monocyte Chemoattractant Protein-1 Levels with Cardiovascular Mortality : A Meta-analysis of Population-Based Studies
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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American Medical Association (AMA),2021
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6 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:48d32f75-e426-4b65-ba7e-0531aa8e8b51
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https://lup.lub.lu.se/record/48d32f75-e426-4b65-ba7e-0531aa8e8b51URI
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https://doi.org/10.1001/jamacardio.2020.5392DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Importance: Human genetics and studies in experimental models support a key role of monocyte-chemoattractant protein-1 (MCP-1) in atherosclerosis. Yet, the associations of circulating MCP-1 levels with risk of coronary heart disease and cardiovascular death in the general population remain largely unexplored. Objective: To explore whether circulating levels of MCP-1 are associated with risk of incident coronary heart disease, myocardial infarction, and cardiovascular mortality in the general population. Data Sources and Selection: Population-based cohort studies, identified through a systematic review, that have examined associations of circulating MCP-1 levels with cardiovascular end points. Data Extraction and Synthesis: Using a prespecified harmonized analysis plan, study-specific summary data were obtained from Cox regression models after excluding individuals with overt cardiovascular disease at baseline. Derived hazard ratios (HRs) were synthesized using random-effects meta-analyses. Main Outcomes and Measures: Incident coronary heart disease (myocardial infarction, coronary revascularization, and unstable angina), nonfatal myocardial infarction, and cardiovascular death (from cardiac or cerebrovascular causes). Results: The meta-analysis included 7 cohort studies involving 21401 individuals (mean [SD] age, 53.7 [10.2] years; 10012 men [46.8%]). Mean (SD) follow-up was 15.3 (4.5) years (326392 person-years at risk). In models adjusting for age, sex, and race/ethnicity, higher MCP-1 levels at baseline were associated with increased risk of coronary heart disease (HR per 1-SD increment in MCP-1 levels: 1.06 [95% CI, 1.01-1.11]; P =.01), nonfatal myocardial infarction (HR, 1.07 [95% CI, 1.01-1.13]; P =.02), and cardiovascular death (HR, 1.12 [95% CI, 1.05-1.20]; P <.001). In analyses comparing MCP-1 quartiles, these associations followed dose-response patterns. After additionally adjusting for vascular risk factors, the risk estimates were attenuated, but the associations of MCP-1 levels with cardiovascular death remained statistically significant, as did the association of MCP-1 levels in the upper quartile with coronary heart disease. There was no significant heterogeneity; the results did not change in sensitivity analyses excluding events occurring in the first 5 years after MCP-1 measurement, and the risk estimates were stable after additional adjustments for circulating levels of interleukin-6 and high-sensitivity C-reactive protein. Conclusions and Relevance: Higher circulating MCP-1 levels are associated with higher long-term cardiovascular mortality in community-dwelling individuals free of overt cardiovascular disease. These findings provide further support for a key role of MCP-1-signaling in cardiovascular disease..
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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De Lemos, James A.University of Texas Southwestern Medical Center
(författare)
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Ayers, ColbyUniversity of Texas Southwestern Medical Center
(författare)
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Wang, BiqiBoston University
(författare)
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Björkbacka, HarryLund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups(Swepub:lu)medf-hbj
(författare)
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Pana, Tiberiu A.University of Aberdeen
(författare)
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Thorand, BarbaraGerman Center for Diabetes Research,Helmholtz Zentrum München
(författare)
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Sun, CarolineBaylor College of Medicine
(författare)
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Fani, LanaErasmus University Medical Center
(författare)
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Malik, RainerUniversity Hospital Munich,Ludwig-Maximilian University of Munich
(författare)
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Dupuis, JoséeBoston University
(författare)
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Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen
(författare)
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Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor
(författare)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(författare)
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Boekholdt, S. MatthijsAmsterdam UMC - Vrije Universiteit Amsterdam,University of Amsterdam
(författare)
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Zierer, AstridHelmholtz Zentrum München
(författare)
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Elhadad, Mohamed A.German Centre for Cardiovascular Research,Helmholtz Zentrum München
(författare)
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Koenig, WolfgangGerman Heart Centre, Munich,German Centre for Cardiovascular Research,University of Ulm,Technical University of Munich
(författare)
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Herder, ChristianHeinrich Heine University Düsseldorf,German Center for Diabetes Research
(författare)
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Hoogeveen, Ron C.Baylor College of Medicine
(författare)
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Kavousi, MaryamErasmus University Medical Center
(författare)
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Ballantyne, Christie M.Baylor College of Medicine
(författare)
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Peters, AnnetteGerman Centre for Cardiovascular Research,Ludwig-Maximilian University of Munich,Helmholtz Zentrum München
(författare)
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Myint, Phyo K.University of Aberdeen
(författare)
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Nilsson, JanLund University,Lunds universitet(Swepub:lu)medf-jni
(författare)
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Benjamin, Emelia J.Framingham Heart Study,National Heart Lung and Blood Institute,Boston University
(författare)
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Dichgans, MartinMunich Cluster for Systems Neurology,University Hospital Munich,Ludwig-Maximilian University of Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn
(författare)
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University Hospital MunichLudwig-Maximilian University of Munich
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:JAMA Cardiology: American Medical Association (AMA)6:5, s. 587-5922380-6583
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- Av författaren/redakt...
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Georgakis, Mario ...
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De Lemos, James ...
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Ayers, Colby
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Wang, Biqi
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Björkbacka, Harr ...
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Pana, Tiberiu A.
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visa fler...
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Thorand, Barbara
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Sun, Caroline
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Fani, Lana
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Malik, Rainer
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Dupuis, Josée
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Engström, Gunnar
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Orho-Melander, M ...
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Melander, Olle
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Boekholdt, S. Ma ...
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Zierer, Astrid
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Elhadad, Mohamed ...
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Koenig, Wolfgang
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Herder, Christia ...
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Hoogeveen, Ron C ...
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Kavousi, Maryam
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Ballantyne, Chri ...
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Peters, Annette
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Myint, Phyo K.
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Nilsson, Jan
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Benjamin, Emelia ...
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Dichgans, Martin
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