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  • Georgakis, Marios K.University Hospital Munich,Ludwig-Maximilian University of Munich (författare)

Association of Circulating Monocyte Chemoattractant Protein-1 Levels with Cardiovascular Mortality : A Meta-analysis of Population-Based Studies

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • American Medical Association (AMA),2021
  • 6 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:48d32f75-e426-4b65-ba7e-0531aa8e8b51
  • https://lup.lub.lu.se/record/48d32f75-e426-4b65-ba7e-0531aa8e8b51URI
  • https://doi.org/10.1001/jamacardio.2020.5392DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Importance: Human genetics and studies in experimental models support a key role of monocyte-chemoattractant protein-1 (MCP-1) in atherosclerosis. Yet, the associations of circulating MCP-1 levels with risk of coronary heart disease and cardiovascular death in the general population remain largely unexplored. Objective: To explore whether circulating levels of MCP-1 are associated with risk of incident coronary heart disease, myocardial infarction, and cardiovascular mortality in the general population. Data Sources and Selection: Population-based cohort studies, identified through a systematic review, that have examined associations of circulating MCP-1 levels with cardiovascular end points. Data Extraction and Synthesis: Using a prespecified harmonized analysis plan, study-specific summary data were obtained from Cox regression models after excluding individuals with overt cardiovascular disease at baseline. Derived hazard ratios (HRs) were synthesized using random-effects meta-analyses. Main Outcomes and Measures: Incident coronary heart disease (myocardial infarction, coronary revascularization, and unstable angina), nonfatal myocardial infarction, and cardiovascular death (from cardiac or cerebrovascular causes). Results: The meta-analysis included 7 cohort studies involving 21401 individuals (mean [SD] age, 53.7 [10.2] years; 10012 men [46.8%]). Mean (SD) follow-up was 15.3 (4.5) years (326392 person-years at risk). In models adjusting for age, sex, and race/ethnicity, higher MCP-1 levels at baseline were associated with increased risk of coronary heart disease (HR per 1-SD increment in MCP-1 levels: 1.06 [95% CI, 1.01-1.11]; P =.01), nonfatal myocardial infarction (HR, 1.07 [95% CI, 1.01-1.13]; P =.02), and cardiovascular death (HR, 1.12 [95% CI, 1.05-1.20]; P <.001). In analyses comparing MCP-1 quartiles, these associations followed dose-response patterns. After additionally adjusting for vascular risk factors, the risk estimates were attenuated, but the associations of MCP-1 levels with cardiovascular death remained statistically significant, as did the association of MCP-1 levels in the upper quartile with coronary heart disease. There was no significant heterogeneity; the results did not change in sensitivity analyses excluding events occurring in the first 5 years after MCP-1 measurement, and the risk estimates were stable after additional adjustments for circulating levels of interleukin-6 and high-sensitivity C-reactive protein. Conclusions and Relevance: Higher circulating MCP-1 levels are associated with higher long-term cardiovascular mortality in community-dwelling individuals free of overt cardiovascular disease. These findings provide further support for a key role of MCP-1-signaling in cardiovascular disease..

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • De Lemos, James A.University of Texas Southwestern Medical Center (författare)
  • Ayers, ColbyUniversity of Texas Southwestern Medical Center (författare)
  • Wang, BiqiBoston University (författare)
  • Björkbacka, HarryLund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups(Swepub:lu)medf-hbj (författare)
  • Pana, Tiberiu A.University of Aberdeen (författare)
  • Thorand, BarbaraGerman Center for Diabetes Research,Helmholtz Zentrum München (författare)
  • Sun, CarolineBaylor College of Medicine (författare)
  • Fani, LanaErasmus University Medical Center (författare)
  • Malik, RainerUniversity Hospital Munich,Ludwig-Maximilian University of Munich (författare)
  • Dupuis, JoséeBoston University (författare)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (författare)
  • Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (författare)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (författare)
  • Boekholdt, S. MatthijsAmsterdam UMC - Vrije Universiteit Amsterdam,University of Amsterdam (författare)
  • Zierer, AstridHelmholtz Zentrum München (författare)
  • Elhadad, Mohamed A.German Centre for Cardiovascular Research,Helmholtz Zentrum München (författare)
  • Koenig, WolfgangGerman Heart Centre, Munich,German Centre for Cardiovascular Research,University of Ulm,Technical University of Munich (författare)
  • Herder, ChristianHeinrich Heine University Düsseldorf,German Center for Diabetes Research (författare)
  • Hoogeveen, Ron C.Baylor College of Medicine (författare)
  • Kavousi, MaryamErasmus University Medical Center (författare)
  • Ballantyne, Christie M.Baylor College of Medicine (författare)
  • Peters, AnnetteGerman Centre for Cardiovascular Research,Ludwig-Maximilian University of Munich,Helmholtz Zentrum München (författare)
  • Myint, Phyo K.University of Aberdeen (författare)
  • Nilsson, JanLund University,Lunds universitet(Swepub:lu)medf-jni (författare)
  • Benjamin, Emelia J.Framingham Heart Study,National Heart Lung and Blood Institute,Boston University (författare)
  • Dichgans, MartinMunich Cluster for Systems Neurology,University Hospital Munich,Ludwig-Maximilian University of Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn (författare)
  • University Hospital MunichLudwig-Maximilian University of Munich (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:JAMA Cardiology: American Medical Association (AMA)6:5, s. 587-5922380-6583

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