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Association of Circ...
Association of Circulating Monocyte Chemoattractant Protein-1 Levels with Cardiovascular Mortality : A Meta-analysis of Population-Based Studies
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- Georgakis, Marios K. (författare)
- Ludwig-Maximilian University of Munich,University Hospital Munich
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- De Lemos, James A. (författare)
- University of Texas Southwestern Medical Center
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- Ayers, Colby (författare)
- University of Texas Southwestern Medical Center
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- Wang, Biqi (författare)
- Boston University
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- Björkbacka, Harry (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups
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- Pana, Tiberiu A. (författare)
- University of Aberdeen
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- Thorand, Barbara (författare)
- German Center for Diabetes Research,Helmholtz Zentrum München
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- Sun, Caroline (författare)
- Baylor College of Medicine
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- Fani, Lana (författare)
- Erasmus University Medical Center
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- Malik, Rainer (författare)
- University Hospital Munich,Ludwig-Maximilian University of Munich
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- Dupuis, Josée (författare)
- Boston University
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Orho-Melander, Marju (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Boekholdt, S. Matthijs (författare)
- University of Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Zierer, Astrid (författare)
- Helmholtz Zentrum München
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- Elhadad, Mohamed A. (författare)
- German Centre for Cardiovascular Research,Helmholtz Zentrum München
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- Koenig, Wolfgang (författare)
- German Heart Centre, Munich,German Centre for Cardiovascular Research,Technical University of Munich,University of Ulm
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- Herder, Christian (författare)
- Heinrich Heine University Düsseldorf,German Center for Diabetes Research
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- Hoogeveen, Ron C. (författare)
- Baylor College of Medicine
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- Kavousi, Maryam (författare)
- Erasmus University Medical Center
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- Ballantyne, Christie M. (författare)
- Baylor College of Medicine
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- Peters, Annette (författare)
- Helmholtz Zentrum München,Ludwig-Maximilian University of Munich,German Centre for Cardiovascular Research
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- Myint, Phyo K. (författare)
- University of Aberdeen
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- Nilsson, Jan (författare)
- Lund University,Lunds universitet
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- Benjamin, Emelia J. (författare)
- Framingham Heart Study,Boston University,National Heart Lung and Blood Institute
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- Dichgans, Martin (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Munich,Ludwig-Maximilian University of Munich,Munich Cluster for Systems Neurology
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(creator_code:org_t)
- American Medical Association (AMA), 2021
- 2021
- Engelska 6 s.
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Ingår i: JAMA Cardiology. - : American Medical Association (AMA). - 2380-6583. ; 6:5, s. 587-592
- Relaterad länk:
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http://dx.doi.org/10...
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https://jamanetwork....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Importance: Human genetics and studies in experimental models support a key role of monocyte-chemoattractant protein-1 (MCP-1) in atherosclerosis. Yet, the associations of circulating MCP-1 levels with risk of coronary heart disease and cardiovascular death in the general population remain largely unexplored. Objective: To explore whether circulating levels of MCP-1 are associated with risk of incident coronary heart disease, myocardial infarction, and cardiovascular mortality in the general population. Data Sources and Selection: Population-based cohort studies, identified through a systematic review, that have examined associations of circulating MCP-1 levels with cardiovascular end points. Data Extraction and Synthesis: Using a prespecified harmonized analysis plan, study-specific summary data were obtained from Cox regression models after excluding individuals with overt cardiovascular disease at baseline. Derived hazard ratios (HRs) were synthesized using random-effects meta-analyses. Main Outcomes and Measures: Incident coronary heart disease (myocardial infarction, coronary revascularization, and unstable angina), nonfatal myocardial infarction, and cardiovascular death (from cardiac or cerebrovascular causes). Results: The meta-analysis included 7 cohort studies involving 21401 individuals (mean [SD] age, 53.7 [10.2] years; 10012 men [46.8%]). Mean (SD) follow-up was 15.3 (4.5) years (326392 person-years at risk). In models adjusting for age, sex, and race/ethnicity, higher MCP-1 levels at baseline were associated with increased risk of coronary heart disease (HR per 1-SD increment in MCP-1 levels: 1.06 [95% CI, 1.01-1.11]; P =.01), nonfatal myocardial infarction (HR, 1.07 [95% CI, 1.01-1.13]; P =.02), and cardiovascular death (HR, 1.12 [95% CI, 1.05-1.20]; P <.001). In analyses comparing MCP-1 quartiles, these associations followed dose-response patterns. After additionally adjusting for vascular risk factors, the risk estimates were attenuated, but the associations of MCP-1 levels with cardiovascular death remained statistically significant, as did the association of MCP-1 levels in the upper quartile with coronary heart disease. There was no significant heterogeneity; the results did not change in sensitivity analyses excluding events occurring in the first 5 years after MCP-1 measurement, and the risk estimates were stable after additional adjustments for circulating levels of interleukin-6 and high-sensitivity C-reactive protein. Conclusions and Relevance: Higher circulating MCP-1 levels are associated with higher long-term cardiovascular mortality in community-dwelling individuals free of overt cardiovascular disease. These findings provide further support for a key role of MCP-1-signaling in cardiovascular disease..
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Georgakis, Mario ...
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De Lemos, James ...
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Ayers, Colby
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Wang, Biqi
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Björkbacka, Harr ...
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Pana, Tiberiu A.
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visa fler...
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Thorand, Barbara
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Sun, Caroline
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Fani, Lana
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Malik, Rainer
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Dupuis, Josée
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Engström, Gunnar
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Orho-Melander, M ...
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Melander, Olle
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Boekholdt, S. Ma ...
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Zierer, Astrid
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Elhadad, Mohamed ...
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Koenig, Wolfgang
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Herder, Christia ...
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Hoogeveen, Ron C ...
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Kavousi, Maryam
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Ballantyne, Chri ...
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Peters, Annette
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Myint, Phyo K.
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Nilsson, Jan
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Benjamin, Emelia ...
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Dichgans, Martin
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JAMA Cardiology
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