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Lung deposition of ...
Lung deposition of surfactant delivered via a dedicated laryngeal mask airway in piglets
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- Nord, Anders (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Cunha-Goncalves, Doris (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk och experimentell lungtransplantation,Forskargrupper vid Lunds universitet,Barnanestesi och intensivvård,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical and experimental lung transplantation,Lund University Research Groups,Pediatric anesthesia and intensive care
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- Linnér, Rikard (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnanestesi och intensivvård,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric anesthesia and intensive care,Lund University Research Groups
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- Bianco, Federico (author)
- Chiesi Farmaceutici S.p.A.
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- Salomone, Fabrizio (author)
- Chiesi Farmaceutici S.p.A.
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- Ricci, Francesca (author)
- Chiesi Farmaceutici S.p.A.
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- Lombardini, Marta (author)
- Chiesi Farmaceutici S.p.A.
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- Micaglio, Massimo (author)
- Careggi University Hospital
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- Trevisanuto, Daniele (author)
- University of Padova
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- Perez-De-sa, Valeria (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnanestesi och intensivvård,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric anesthesia and intensive care,Lund University Research Groups
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(creator_code:org_t)
- 2021-11-04
- 2021
- English.
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In: Pharmaceutics. - : MDPI AG. - 1999-4923. ; 13:11
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Abstract
Subject headings
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- It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg·kg−1 of poractant alfa mixed with99mTechnetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10–85), 41% (5–88), and 88% (67–92) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (p < 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Laryngeal mask airway
- Lung deposition
- Newborn
- Scintigraphy
- Surfactant
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Nord, Anders
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Cunha-Goncalves, ...
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Linnér, Rikard
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Bianco, Federico
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Salomone, Fabriz ...
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Ricci, Francesca
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Lombardini, Mart ...
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Micaglio, Massim ...
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Trevisanuto, Dan ...
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Perez-De-sa, Val ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Pharmaceutics
- By the university
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Lund University