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Oxygen targets and ...
Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
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- Robba, Chiara (författare)
- University of Genoa,San Martino Policlin Hosp, Italy; Univ Genoa, Italy
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- Lilja, Gisela (författare)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden
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- Friberg, Hans (författare)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Center for cardiac arrest,Lund University Research Groups,Lund Univ, Sweden
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- Chew, Michelle S. (författare)
- Linköpings universitet,Linköping University,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US,Skåne University Hospital
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- Unden, Johan (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Halmstad County Hospital,Lund Univ, Sweden; Lund Univ, Sweden,Helsingborg Hospital
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- Dankiewicz, Josef (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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- Nielsen, Niklas (författare)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital,Lund Univ, Sweden
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- Ebner, Florian (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Helsingborg Hospital,Lund Univ, Sweden
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- Pelosi, Paolo (författare)
- University of Genoa,San Martino Policlin Hosp, Italy; Univ Genoa, Italy
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- Cronberg, Tobias (creator_code:cre_t)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups
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- Erlinge, David (creator_code:cre_t)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups
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- Levin, Helena (creator_code:cre_t)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups
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- Nordberg, Per (creator_code:cre_t)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ullén, Susann (creator_code:cre_t)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Palmér, Karolina (creator_code:cre_t)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Karlsson, Ulla Britt (creator_code:cre_t)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Heissler, Simon (creator_code:cre_t)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ceric, Ameldina (creator_code:cre_t)
- Helsingborg Hospital
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- Haxhija, Zana (creator_code:cre_t)
- Helsingborg Hospital
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- Düring, Joachim (creator_code:cre_t)
- Skåne University Hospital
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- Bergström, Mattias (creator_code:cre_t)
- Skåne University Hospital
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- Bohm, Mattias (creator_code:cre_t)
- Skåne University Hospital
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- Didriksson, Ingrid (creator_code:cre_t)
- Skåne University Hospital
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- Frid, Petrea (creator_code:cre_t)
- Skåne University Hospital
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- Heimburg, Katarina (creator_code:cre_t)
- Skåne University Hospital
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- Lundberg, Oscar (creator_code:cre_t)
- Skåne University Hospital
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- Hau, Stefan Olsson (creator_code:cre_t)
- Skåne University Hospital
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- Schmidbauer, Simon (creator_code:cre_t)
- Skåne University Hospital
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- Borgquist, Ola (creator_code:cre_t)
- Skåne University Hospital
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- Bjärnroos, Anna (creator_code:cre_t)
- Skåne University Hospital
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- Blennow Nordström, Erik (creator_code:cre_t)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Dragancea, Irina (creator_code:cre_t)
- Skåne University Hospital
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- Kander, Thomas (creator_code:cre_t)
- Skåne University Hospital
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- Lybeck, Anna (creator_code:cre_t)
- Skåne University Hospital
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- Mattiasson, Gustav (creator_code:cre_t)
- Skåne University Hospital
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- Rundgren, Malin (creator_code:cre_t)
- Skåne University Hospital
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- Westhall, Erik (creator_code:cre_t)
- Skåne University Hospital
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- Annborn, Martin (creator_code:cre_t)
- Helsingborg Hospital,Lund Univ, Sweden
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- Andertun, Sara (creator_code:cre_t)
- Helsingborg Hospital
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- Johnsson, Jesper (creator_code:cre_t)
- Karolinska Institutet
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- Unden, Johan (creator_code:cre_t)
- Helsingborg Hospital
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Wijdicks, Eelco F. M. (creator_code:cre_t)
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- Badenes, Rafael (författare)
- Univ Valencia, Spain; Univ Valencia, Spain
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- Battaglini, Denise (författare)
- San Martino Policlin Hosp, Italy; Univ Barcelona, Spain
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- Ball, Lorenzo (författare)
- San Martino Policlin Hosp, Italy; Univ Genoa, Italy
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- Sanfilippo, Filippo (författare)
- AOU Policlin San Marco, Italy
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- Brunetti, Iole (författare)
- San Martino Policlin Hosp, Italy
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- Jakobsen, Janus Christian (författare)
- Copenhagen Univ Hosp, Denmark; Univ Southern Denmark, Denmark
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- Wendel-Garcia, Pedro David (författare)
- Univ Hosp Zurich, Switzerland
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- Eastwood, Glenn (författare)
- Monash Univ, Australia; Austin Hosp, Australia
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- Thomas, Matthew (författare)
- Univ Hosp Bristol NHS Fdn Trust, England
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- Joannidis, Michael (författare)
- Med Univ Innsbruck, Austria
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- Nichol, Alistair (författare)
- Monash Univ, Australia
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- Lundin, Andreas (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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- Hollenberg, Jacob (författare)
- Karolinska Inst, Sweden
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- Hammond, Naomi (författare)
- UNSW Sydney, Australia
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- Saxena, Manoj (författare)
- St George Hosp, Australia
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- Solar, Miroslav (författare)
- Charles Univ Prague, Czech Republic; Univ Hosp Hradec Kralove, Czech Republic
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- Taccone, Fabio Silvio (författare)
- Univ Libre Bruxelles, Belgium
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- Grejs, Anders Morten (författare)
- Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark
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(creator_code:org_t)
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- 2022-10-21
- 2022
- Engelska.
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Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535 .- 1466-609X. ; 26, s. 1-13
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://liu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO2 with patients’ outcome. Methods: Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO2 < 60 mmHg and severe hyperoxemia as PaO2 > 300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results: 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO2-AUC), for hyperoxemia was significantly associated with mortality (p = 0.003). Conclusions: In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration: clinicaltrials.gov NCT02908308, Registered September 20, 2016.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Cardiac arrest
- Hyperoxemia
- Hypoxemia
- Mortality
- Neurological outcome
- Cardiac arrest; Hypoxemia; Hyperoxemia; Mortality; Neurological outcome
- arterial oxygen
- carbon-dioxide
- hyperoxia
- resuscitation
- association
- cardiopulmonary
- survival
- care
- prognostication
- epidemiology
- General & Internal Medicine
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Robba, Chiara
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Lilja, Gisela
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Friberg, Hans
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Chew, Michelle S ...
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Unden, Johan
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Dankiewicz, Jose ...
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visa fler...
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Nielsen, Niklas
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Ebner, Florian
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Pelosi, Paolo
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Cronberg, Tobias
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Erlinge, David
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Levin, Helena
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Nordberg, Per
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Ullén, Susann
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Palmér, Karolina
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Karlsson, Ulla B ...
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Heissler, Simon
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Ceric, Ameldina
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Haxhija, Zana
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Düring, Joachim
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Bergström, Matti ...
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Bohm, Mattias
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Didriksson, Ingr ...
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Frid, Petrea
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Heimburg, Katari ...
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Lundberg, Oscar
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Hau, Stefan Olss ...
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Schmidbauer, Sim ...
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Borgquist, Ola
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Bjärnroos, Anna
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Blennow Nordströ ...
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Dragancea, Irina
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Kander, Thomas
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Lybeck, Anna
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Mattiasson, Gust ...
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Rundgren, Malin
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Westhall, Erik
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Annborn, Martin
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Andertun, Sara
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Johnsson, Jesper
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Wijdicks, Eelco ...
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Badenes, Rafael
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Battaglini, Deni ...
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Ball, Lorenzo
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Sanfilippo, Fili ...
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Brunetti, Iole
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Jakobsen, Janus ...
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Wendel-Garcia, P ...
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Eastwood, Glenn
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Thomas, Matthew
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Joannidis, Micha ...
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Nichol, Alistair
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Lundin, Andreas
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Hollenberg, Jaco ...
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Hammond, Naomi
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Saxena, Manoj
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Solar, Miroslav
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Taccone, Fabio S ...
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Grejs, Anders Mo ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Anestesi och int ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Critical Care
- Av lärosätet
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Lunds universitet
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Linköpings universitet
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Karolinska Institutet
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Göteborgs universitet