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Lifestyle factors a...
Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases : a multinational cohort study
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer, World Health Organization
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- Viallon, Vivian (författare)
- International Agency for Research on Cancer, World Health Organization
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- Lennon, Hannah (författare)
- International Agency for Research on Cancer, World Health Organization
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visa fler...
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- Bagnardi, Vincenzo (författare)
- University of Milano-Bicocca
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- Ricci, Cristian (författare)
- North-West University
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- Butterworth, Adam S. (författare)
- University of Cambridge
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- Sweeting, Michael (författare)
- University of Cambridge
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- Muller, David (författare)
- Imperial College London
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- Romieu, Isabelle (författare)
- International Agency for Research on Cancer, World Health Organization
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- Bazelle, Pauline (författare)
- International Agency for Research on Cancer, World Health Organization
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- Kvaskoff, Marina (författare)
- Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
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- Arveux, Patrick (författare)
- Centre for Research in Epidemiology and Population Health (CESP),Breast and Gynaecologic Cancer Registry of Côte d'Or,Centre Georges-François Leclerc
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- Severi, Gianluca (författare)
- Human Genetics Foundation (HuGeF),Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
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- Bamia, Christina (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Bergmann, Manuela (författare)
- German Institute of Human Nutrition
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Olsen, Anja (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University
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- Dahm, Christina C. (författare)
- Aarhus University
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- Menéndez, Virginia (författare)
- Public Health Directorate
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- Agudo, Antonio (författare)
- Bellvitge University Hospital-IDIBELL,Bellvitge Biomedical Research Institute,L'Hospitalet de Llobregat, Barcelona,University of Oxford
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- Sánchez, Maria Jose (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Amiano, Pilar (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute
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- Santiuste, Carmen (författare)
- Murcia Regional Health Council
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- Gurrea, Aurelio Barricarte (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Tong, Tammy Y.N. (författare)
- University of Oxford
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- Schmidt, Julie A. (författare)
- University of Oxford
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- Tzoulaki, Ioanna (författare)
- University of Ioannina,Imperial College London
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- Tsilidis, Konstantinos K. (författare)
- University of Ioannina,Imperial College London
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- Ward, Heather (författare)
- Imperial College London
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- Palli, Domenico (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Agnoli, Claudia (författare)
- Istituto Nazionale dei Tumori
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Ricceri, Fulvio (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Picavet, H. Susan J. (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Bakker, Marije (författare)
- University Medical Center Utrecht
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- Monninkhof, Evelyn (författare)
- University Medical Center Utrecht
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- Nilsson, Peter (författare)
- Umeå universitet,Umeå University,Näringsforskning
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Rolandsson, Olov (författare)
- Umeå universitet,Umeå University,Allmänmedicin
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- Thysell, Elin (författare)
- Umeå University
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (författare)
- Imperial College London
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- Vineis, Paolo (författare)
- Imperial College London
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- Danesh, John (författare)
- University of Cambridge
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- Wareham, Nick J (författare)
- University of Cambridge
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2020-01-10
- 2020
- Engelska.
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Ingår i: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 18:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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https://bmcmedicine....
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. METHODS: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. RESULTS: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and women with healthy lifestyles. CONCLUSION: Pre-diagnostic healthy lifestyle behaviours were strongly inversely associated with the risk of cancer and cardiometabolic diseases, and with the prognosis of these diseases by reducing risk of multimorbidity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Cancer
- Cancer and cardiometabolic multimorbidity
- Cardiovascular disease
- Diabetes
- Healthy lifestyle
- Obesity
- Prevention
- Cancer
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Freisling, Heinz
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Viallon, Vivian
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Lennon, Hannah
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Bagnardi, Vincen ...
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Ricci, Cristian
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Butterworth, Ada ...
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visa fler...
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Sweeting, Michae ...
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Muller, David
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Romieu, Isabelle
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Bazelle, Pauline
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Kvaskoff, Marina
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Arveux, Patrick
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Severi, Gianluca
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Bamia, Christina
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Kühn, Tilman
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Kaaks, Rudolf
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Bergmann, Manuel ...
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Boeing, Heiner
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Kim
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Dahm, Christina ...
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Menéndez, Virgin ...
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Agudo, Antonio
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Sánchez, Maria J ...
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Amiano, Pilar
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Santiuste, Carme ...
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Gurrea, Aurelio ...
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Tong, Tammy Y.N.
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Schmidt, Julie A ...
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Tzoulaki, Ioanna
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Tsilidis, Konsta ...
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Ward, Heather
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Palli, Domenico
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Agnoli, Claudia
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Tumino, Rosario
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Ricceri, Fulvio
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Panico, Salvator ...
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Picavet, H. Susa ...
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Bakker, Marije
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Monninkhof, Evel ...
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Nilsson, Peter
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Manjer, Jonas
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Rolandsson, Olov
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Thysell, Elin
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Weiderpass, Elis ...
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Jenab, Mazda
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Riboli, Elio
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Vineis, Paolo
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Danesh, John
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Wareham, Nick J
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Gunter, Marc J.
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Ferrari, Pietro
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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BMC Medicine
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Lunds universitet
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