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Ejection fraction i...
Ejection fraction in left bundle branch block is disproportionately reduced in relation to amount of myocardial scar
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- Axelsson, Jimmy (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Wieslander, Björn (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Jablonowski, Robert (författare)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Klem, Igor (författare)
- Duke University Medical Center
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- Nijveldt, Robin (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Schelbert, Erik B. (författare)
- University of Pittsburgh Medical Center
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- Sörensson, Peder (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Sigfridsson, Andreas (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Chaudhry, Uzma (författare)
- Lund University,Lunds universitet,Arrhytmias and Cardiac Device treatment,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Platonov, Pyotr G. (författare)
- Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Borgquist, Rasmus (författare)
- Lund University,Lunds universitet,Clinical studies af Atrial Fibrillation,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Engblom, Henrik (författare)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Strauss, David G. (författare)
- Karolinska Institutet,United States Food and Drug Administration,Karolinska University Hospital
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- Arheden, Håkan (författare)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Atwater, Brett D. (författare)
- Duke University Medical Center
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- Ugander, Martin (författare)
- Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska 6 s.
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Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 0022-0736 .- 1532-8430. ; 51:6, s. 1071-1076
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: The relationship between left ventricular (LV) ejection fraction (EF) and LV myocardial scar can identify potentially reversible causes of LV dysfunction. Left bundle branch block (LBBB) alters the electrical and mechanical activation of the LV. We hypothesized that the relationship between LVEF and scar extent is different in LBBB compared to controls. Methods: We compared the relationship between LVEF and scar burden between patients with LBBB and scar (n = 83), and patients with chronic ischemic heart disease and scar but no electrocardiographic conduction abnormality (controls, n = 90), who had undergone cardiovascular magnetic resonance (CMR) imaging at one of three centers. LVEF (%) was measured in CMR cine images. Scar burden was quantified by CMR late gadolinium enhancement (LGE) and expressed as % of LV mass (%LVM). Maximum possible LVEF (LVEFmax) was defined as the function describing the hypotenuse in the LVEF versus myocardial scar extent scatter plot. Dysfunction index was defined as LVEFmax derived from the control cohort minus the measured LVEF. Results: Compared to controls with scar, LBBB with scar had a lower LVEF (median [interquartile range] 27 [19–38] vs 36 [25–50] %, p < 0.001), smaller scar (4 [1–9] vs 11 [6–20] %LVM, p < 0.001), and greater dysfunction index (39 [30–52] vs 21 [12–35] % points, p < 0.001). Conclusions: Among LBBB patients referred for CMR, LVEF is disproportionately reduced in relation to the amount of scar. Dyssynchrony in LBBB may thus impair compensation for loss of contractile myocardium.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Left bundle branch block
- Left ventricular ejection fraction
- Magnetic resonance imaging
- Myocardial scarring
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Axelsson, Jimmy
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Wieslander, Björ ...
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Jablonowski, Rob ...
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Klem, Igor
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Nijveldt, Robin
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Schelbert, Erik ...
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visa fler...
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Sörensson, Peder
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Sigfridsson, And ...
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Chaudhry, Uzma
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Platonov, Pyotr ...
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Borgquist, Rasmu ...
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Engblom, Henrik
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Strauss, David G ...
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Arheden, Håkan
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Atwater, Brett D ...
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Ugander, Martin
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
- Artiklar i publikationen
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Journal of Elect ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet