Sökning: (L773:0036 8075 OR L773:1095 9203) srt2:(1980-1989)
> (1985) >
Hypoglycemia-induce...
-
Wieloch, TadeuszLund University,Lunds universitet,Laboratory for Experimental Brain Research,Forskargrupper vid Lunds universitet,Lund University Research Groups
(författare)
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist
- Artikel/kapitelEngelska1985
Förlag, utgivningsår, omfång ...
-
American Association for the Advancement of Science (AAAS),1985
-
3 s.
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:4974837b-f849-4ea8-9fb9-9705b16ec771
-
https://lup.lub.lu.se/record/4974837b-f849-4ea8-9fb9-9705b16ec771URI
-
https://doi.org/10.1126/science.2996146DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Laboratory for Experimental Brain ResearchForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Science: American Association for the Advancement of Science (AAAS)230:4726, s. 681-6830036-80751095-9203
Internetlänk
Hitta via bibliotek
-
Science
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas