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- Nylander, K.Umeå University (author)
A non-random deletion in the p53 gene in oral squamous cell carcinoma
- Article/chapterEnglish1996
Publisher, publication year, extent ...
- Springer Science and Business Media LLC,1996
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:49e56649-dbbc-4b79-bb3d-58385d810d2b
- https://lup.lub.lu.se/record/49e56649-dbbc-4b79-bb3d-58385d810d2bURI
- https://doi.org/10.1038/bjc.1996.262DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Deletion
- Epidemiology
- Head and neck
- p53 gene
- Squamous cell carcinoma
Added entries (persons, corporate bodies, meetings, titles ...)
- Schildt, E. B.Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-esc (author)
- Eriksson, M.Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-mer (author)
- Magnusson, A. (author)
- Mehle, C.Umeå University (author)
- Roos, G.Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-gro (author)
- Umeå UniversityTumörmikromiljö (creator_code:org_t)
Related titles
- In:British Journal of Cancer: Springer Science and Business Media LLC73:11, s. 1381-13860007-09201532-1827
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